Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods. Export

@article{citeulike:694510, abstract = {OBJECTIVE: Cardiac output (CO) has traditionally been measured using invasive techniques, which involve an element of risk. Thus, a reliable less-invasive method for determining CO would be very valuable for research use. We tested whether simple analysis of the arterial pulse waveform, not requiring large-vessel catheterisation or expensive equipment, could provide an estimate of CO that is accurate enough for pharmacological studies. METHODS: We measured CO in 11 healthy male subjects who received low and high doses of dexmedetomidine (alpha(2)-adrenoceptor agonist), using pulse contour analysis, echocardiography and pulmonary thermodilution techniques. RESULTS: At baseline, these methods gave the following mean (SD) values of CO: 6.18 (1.59), 5.22 (1.35) and 7.03 (1.54) l/min, respectively. High-dose dexmedetomidine reduced CO to 4.50 (0.68), 3.65 (0.65) and 4.80 (0.89) l/min, corresponding to -25 (14) \%, -28 (12) \% and -30 (14) \% reductions from baseline, respectively. The pulse contour method described these dexmedetomidine-induced changes in CO very similarly to the thermodilution and echocardiographic methods. The limits of agreement [bias (2SD)] were 0.55 (2.55) and -0.10 (2.04) l/min, respectively. CONCLUSION: The minimally invasive pulse contour analysis technique might be suitable for pharmacological studies for the detection of major drug-induced reductions in CO.}, address = {Turku PET Centre, Turku University Central Hospital, Turku, Finland.}, author = {Penttil\"{a}, J. and Snapir, A. and Kentala, E. and Koskenvuo, J. and Posti, J. and Scheinin, M. and Scheinin, H. and Kuusela, T.}, citeulike-article-id = {694510}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00228-006-0115-1}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16570186}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16570186}, doi = {10.1007/s00228-006-0115-1}, issn = {0031-6970}, journal = {Eur J Clin Pharmacol}, month = {June}, number = {6}, pages = {401--407}, posted-at = {2006-06-13 10:14:20}, priority = {0}, title = {Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods.}, url = {http://dx.doi.org/10.1007/s00228-006-0115-1}, volume = {62}, year = {2006} }

TY - JOUR ID - citeulike:694510 L3 - citeulike-article-id:694510 N2 - OBJECTIVE: Cardiac output (CO) has traditionally been measured using invasive techniques, which involve an element of risk. Thus, a reliable less-invasive method for determining CO would be very valuable for research use. We tested whether simple analysis of the arterial pulse waveform, not requiring large-vessel catheterisation or expensive equipment, could provide an estimate of CO that is accurate enough for pharmacological studies. METHODS: We measured CO in 11 healthy male subjects who received low and high doses of dexmedetomidine (alpha(2)-adrenoceptor agonist), using pulse contour analysis, echocardiography and pulmonary thermodilution techniques. RESULTS: At baseline, these methods gave the following mean (SD) values of CO: 6.18 (1.59), 5.22 (1.35) and 7.03 (1.54) l/min, respectively. High-dose dexmedetomidine reduced CO to 4.50 (0.68), 3.65 (0.65) and 4.80 (0.89) l/min, corresponding to -25 (14) %, -28 (12) % and -30 (14) % reductions from baseline, respectively. The pulse contour method described these dexmedetomidine-induced changes in CO very similarly to the thermodilution and echocardiographic methods. The limits of agreement [bias (2SD)] were 0.55 (2.55) and -0.10 (2.04) l/min, respectively. CONCLUSION: The minimally invasive pulse contour analysis technique might be suitable for pharmacological studies for the detection of major drug-induced reductions in CO. IS - 6 JF - Eur J Clin Pharmacol SN - 0031-6970 AD - Turku PET Centre, Turku University Central Hospital, Turku, Finland. EP - 407 TI - Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods. VL - 62 SP - 401 AU - Penttilä, J AU - Snapir, A AU - Kentala, E AU - Koskenvuo, J AU - Posti, J AU - Scheinin, M AU - Scheinin, H AU - Kuusela, T PY - 2006/06// UR - http://dx.doi.org/10.1007/s00228-006-0115-1 ER -