Intrachain Dynamics of Large dsDNA Confined to Slitlike Channels

Exploration of intrachain hydrodynamics of dsDNA within channels has been limited to indirect analysis of global coil dynamics. In this Letter, we isolate hydrodynamic interactions within single molecules of dsDNA confined to slitlike channels by making use of density covariance measurements. We show that the strength of hydrodynamic interactions in DNA is dependent on the intrachain correlation length and that screening by symmetry in slitlike confinement results in a screening length that is proportional channel height. Moreover, we directly show the partial draining nature of the blobs formed by dsDNA in slits and predict under what conditions a dsDNA blob should obey nondraining Zimm behavior.