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Aggregation of lariat ethers attached to a membrane anchoring unit

by: NK Djedovic, R Ferdani, PH Schlesinger, GW Gokel
Tetrahedron, Vol. 58, No. 51. (2002), pp. 10263-8.


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The GGGPGGG heptapeptide, when anchored by octadecylamineâdiglycolic acid unit forms chloride-selective channels in bilayer. Crown ethers, differently anchored, have been used to form synthetic cation channels. Dialkylamineâdiglycolic acid anchored crown ethers failed to form cation-selective channels. This might be due to an inability to insert in the bilayer. Their ability to form stable aggregates, reflective of the latter, was therefore studied.


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