Time-evolution of enhanced ultrasonic reflection using a fibrin-targeted nanoparticulate contrast agent

@inproceedings{citeulike:2282432, abstract = {Molecular imaging with targeted contrast agents is emerging as an important technological advance for diagnostic ultrasound. In vivo, these agents must bind to and acoustically enhance their targets before the agents are cleared or destroyed. In this study, we present results using a system that was designed and constructed for visualization of the evolution of acoustic contrast enhancement. To evaluate the system, two targets were examined: avidin-complexed nitrocellulose membrane and human plasma clots. The time evolution of enhancement was visualized in 10-minute increments for one hour. A monotonic increase was observed in ultrasonic reflection enhancement from specially treated nitrocellulose membranes for targeted emulsions containing perfluorooctylbromide (1.3\±0.3 dB) and perfluorooctane (2.6\±0.5 dB) within the first 60 minutes of imaging. In comparison, the inherently non-echogenic plasma clots showed a substantial increase of 12.0\±0.9 dB when targeted with a perfluorooctane emulsion. This study demonstrates the concept of molecular imaging and provides the first quantifiable time evolution report of the binding of a site-targeted ultrasonic contrast agent}, author = {Marsh, J. N. and Hall, C. S. and Scott, M. J. and Gaffney, P. J. and Wickline, S. A. and Lanza, G. M. }, booktitle = {Ultrasonics Symposium, 2000 IEEE}, citeulike-article-id = {2282432}, doi = {http://dx.doi.org/10.1109/ULTSYM.2000.921700}, journal = {Ultrasonics Symposium, 2000 IEEE}, keywords = {imaging, nanotech, sccne, ultrasound}, pages = {1927--1930 vol.2}, posted-at = {2008-01-24 16:47:11}, priority = {0}, title = {Time-evolution of enhanced ultrasonic reflection using a fibrin-targeted nanoparticulate contrast agent}, url = {http://dx.doi.org/10.1109/ULTSYM.2000.921700}, volume = {2}, year = {2000} }

TY - CONF ID - citeulike:2282432 L3 - citeulike-article-id:2282432 TI - Time-evolution of enhanced ultrasonic reflection using a fibrin-targeted nanoparticulate contrast agent T2 - Ultrasonics Symposium, 2000 IEEE JF - Ultrasonics Symposium, 2000 IEEE VL - 2 SP - 1927 EP - 1930 vol.2 N2 - Molecular imaging with targeted contrast agents is emerging as an important technological advance for diagnostic ultrasound. In vivo, these agents must bind to and acoustically enhance their targets before the agents are cleared or destroyed. In this study, we present results using a system that was designed and constructed for visualization of the evolution of acoustic contrast enhancement. To evaluate the system, two targets were examined: avidin-complexed nitrocellulose membrane and human plasma clots. The time evolution of enhancement was visualized in 10-minute increments for one hour. A monotonic increase was observed in ultrasonic reflection enhancement from specially treated nitrocellulose membranes for targeted emulsions containing perfluorooctylbromide (1.3±0.3 dB) and perfluorooctane (2.6±0.5 dB) within the first 60 minutes of imaging. In comparison, the inherently non-echogenic plasma clots showed a substantial increase of 12.0±0.9 dB when targeted with a perfluorooctane emulsion. This study demonstrates the concept of molecular imaging and provides the first quantifiable time evolution report of the binding of a site-targeted ultrasonic contrast agent KW - imaging KW - nanotech KW - sccne KW - ultrasound AU - Marsh, JN AU - Hall, CS AU - Scott, MJ AU - Gaffney, PJ AU - Wickline, SA AU - Lanza, GM PY - 2000/// UR - http://dx.doi.org/10.1109/ULTSYM.2000.921700 ER -