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Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis

by: Matthias Nahrendorf, Hanwen Zhang, Sheena Hembrador, Peter Panizzi, David E. Sosnovik, Elena Aikawa, Peter Libby, Filip K. Swirski, Ralph Weissleder
Circulation, Vol. 117, No. 3. (22 January 2008), pp. 379-387, doi:10.1161/circulationaha.107.741181  Key: citeulike:2414576

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Abstract

Background— Macrophages participate centrally in atherosclerosis, and macrophage markers (eg, CD68, MAC-3) correlate well with lesion severity and therapeutic modulation. On the basis of the avidity of lesional macrophages for polysaccharide-containing supramolecular structures such as nanoparticles, we have developed a new positron emission tomography (PET) agent with optimized pharmacokinetics to allow in vivo imaging at tracer concentrations.


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