Amphiphile induced echinocyte-spheroechinocyte transformation of red blood cell shape. Export

@article{citeulike:5445842, abstract = {A possible physical explanation of the echinocyte -spheroechinocyte red blood cell (RBC) shape transformation induced by the intercalation of amphiphilic molecules into the outer layer of the RBC plasma membrane bilayer is given. The stable RBC shape is determined by the minimization of the membrane elastic energy, consisting of the bilayer bending energy, the bilayer relative stretching energy and the skeleton shear elastic energy. It is shown that for a given relative cell volume the calculated number of echinocyte spicula increases while their size decreases as the number of the intercalated amphiphilic molecules in the outer layer of the cell membrane bilayer is increased, which is in agreement with experimental observations. Further, it is show that the equilibrium difference between the outer and the inner membrane leaflet areas of the stable RBC shapes increases if the amount of the intercalated amphiphiles is increased, thereby verifying theoretically the original bilayer couple hypothesis of Sheetz and Singer (1974) and Evans (1974).}, author = {Iglic, A. and Kralj-Iglic, V. and H\"{a}gerstrand, H.}, citeulike-article-id = {5445842}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9691462}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9691462}, issn = {0175-7571}, journal = {European biophysics journal : EBJ}, keywords = {ligand-membrane\_interactions, red\_blood\_cell}, number = {4}, pages = {335--339}, posted-at = {2009-10-16 13:43:12}, priority = {2}, title = {Amphiphile induced echinocyte-spheroechinocyte transformation of red blood cell shape.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9691462}, volume = {27}, year = {1998} }

TY - JOUR ID - citeulike:5445842 L3 - citeulike-article-id:5445842 N2 - A possible physical explanation of the echinocyte -spheroechinocyte red blood cell (RBC) shape transformation induced by the intercalation of amphiphilic molecules into the outer layer of the RBC plasma membrane bilayer is given. The stable RBC shape is determined by the minimization of the membrane elastic energy, consisting of the bilayer bending energy, the bilayer relative stretching energy and the skeleton shear elastic energy. It is shown that for a given relative cell volume the calculated number of echinocyte spicula increases while their size decreases as the number of the intercalated amphiphilic molecules in the outer layer of the cell membrane bilayer is increased, which is in agreement with experimental observations. Further, it is show that the equilibrium difference between the outer and the inner membrane leaflet areas of the stable RBC shapes increases if the amount of the intercalated amphiphiles is increased, thereby verifying theoretically the original bilayer couple hypothesis of Sheetz and Singer (1974) and Evans (1974). IS - 4 JF - European biophysics journal : EBJ SN - 0175-7571 EP - 339 TI - Amphiphile induced echinocyte-spheroechinocyte transformation of red blood cell shape. VL - 27 SP - 335 KW - ligand-membrane_interactions KW - red_blood_cell AU - Iglic, A AU - Kralj-Iglic, V AU - Hägerstrand, H PY - 1998/// UR - http://view.ncbi.nlm.nih.gov/pubmed/9691462 ER -