Interaction of nanoparticles with lipid layers Export

@article{citeulike:6032235, abstract = {Poly (amidoamine) dendrimer nanoparticles are used extensively in diverse biological and medical applications. Examples include gene and drug delivery, where nanoparticles disrupt cell membranes to allow the transport of material into cells. The size and surface chemistry of these particles have a strong effect on their interaction with membranes. This paper proposes a three-dimensional phase-field model to investigate how the interaction drives deformation and morphological evolution of the membrane. Attention is focused on the hole-formation process in the membrane. The simulations have demonstrated that a larger amine-terminated generation 7 dendrimer, which has positive charges, causes the formation of a hole in the membrane. The displaced membrane molecules enclose the particle and form a dendrimer-filled membrane vesicle. The effect is significantly reduced for a smaller dendrimer. An acetamide-terminated dendrimer, which has a neutral charge at the surface, does not cause hole formation. These results agree with experimental observations from atomic force microscopy. The study will provide insight into the design of appropriate nanoparticle surface properties for medical applications.}, author = {Park, Jonghyun and Lu, Wei}, citeulike-article-id = {6032235}, citeulike-linkout-0 = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PLEEE8000080000002021607000001&idtype=cvips&gifs=yes}, citeulike-linkout-1 = {http://link.aps.org/abstract/PRE/v80/e021607}, citeulike-linkout-2 = {http://dx.doi.org/10.1103/PhysRevE.80.021607}, doi = {10.1103/PhysRevE.80.021607}, journal = {Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)}, keywords = {biomembranes, molecular\_simulation, nanoparticles, nanotech}, number = {2}, pages = {021607+}, posted-at = {2009-10-29 13:54:24}, priority = {2}, publisher = {APS}, title = {Interaction of nanoparticles with lipid layers}, url = {http://dx.doi.org/10.1103/PhysRevE.80.021607}, volume = {80}, year = {2009} }

TY - JOUR ID - citeulike:6032235 L3 - citeulike-article-id:6032235 N2 - Poly (amidoamine) dendrimer nanoparticles are used extensively in diverse biological and medical applications. Examples include gene and drug delivery, where nanoparticles disrupt cell membranes to allow the transport of material into cells. The size and surface chemistry of these particles have a strong effect on their interaction with membranes. This paper proposes a three-dimensional phase-field model to investigate how the interaction drives deformation and morphological evolution of the membrane. Attention is focused on the hole-formation process in the membrane. The simulations have demonstrated that a larger amine-terminated generation 7 dendrimer, which has positive charges, causes the formation of a hole in the membrane. The displaced membrane molecules enclose the particle and form a dendrimer-filled membrane vesicle. The effect is significantly reduced for a smaller dendrimer. An acetamide-terminated dendrimer, which has a neutral charge at the surface, does not cause hole formation. These results agree with experimental observations from atomic force microscopy. The study will provide insight into the design of appropriate nanoparticle surface properties for medical applications. IS - 2 JF - Physical Review E (Statistical, Nonlinear, and Soft Matter Physics) TI - Interaction of nanoparticles with lipid layers PB - APS VL - 80 SP - 021607 KW - biomembranes KW - molecular_simulation KW - nanoparticles KW - nanotech AU - Park, Jonghyun AU - Lu, Wei PY - 2009/// UR - http://dx.doi.org/10.1103/PhysRevE.80.021607 ER -