Delivery and Efficacy of a Cancer Drug as a Function of the Bond to the Gold Nanoparticle Surface Export

@article{citeulike:6045703, abstract = {PMID: 19719162 In this feature article, gold nanoparticle conjugates loaded with phthalocyanine-based PDT drugs are prepared and tested for delivery efficiency and PDT efficacy on HeLa cancer cells. It could be shown that the delivery and PDT outcome are strongly affected by the bond that links the drug load to the nanoparticle surface. Whereas labile amino adsorption to the Au nanoparticle surface allows for efficient drug release into the cancer cells and for efficient PDT, a covalent thiol bond to the Au nanoparticle leads to the delivery of the drug into cell vesicles, and no PDT effect is observed. This work highlights the importance of carefully choosing the interaction between drug molecules and the nanoparticle surface.}, author = {Cheng, Yu and Samia, Anna C. and Li, Jun and Kenney, Malcolm E. and Resnick, Andrew and Burda, Clemens}, citeulike-article-id = {6045703}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/la902390d}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/la902390d}, doi = {10.1021/la902390d}, journal = {Langmuir}, keywords = {cancer, kinetics, nanotechnology}, number = {0}, posted-at = {2009-10-31 00:37:51}, priority = {2}, title = {Delivery and Efficacy of a Cancer Drug as a Function of the Bond to the Gold Nanoparticle Surface}, url = {http://dx.doi.org/10.1021/la902390d}, volume = {0}, year = {0000} }

TY - JOUR ID - citeulike:6045703 L3 - citeulike-article-id:6045703 N2 - PMID: 19719162 In this feature article, gold nanoparticle conjugates loaded with phthalocyanine-based PDT drugs are prepared and tested for delivery efficiency and PDT efficacy on HeLa cancer cells. It could be shown that the delivery and PDT outcome are strongly affected by the bond that links the drug load to the nanoparticle surface. Whereas labile amino adsorption to the Au nanoparticle surface allows for efficient drug release into the cancer cells and for efficient PDT, a covalent thiol bond to the Au nanoparticle leads to the delivery of the drug into cell vesicles, and no PDT effect is observed. This work highlights the importance of carefully choosing the interaction between drug molecules and the nanoparticle surface. IS - 0 JF - Langmuir TI - Delivery and Efficacy of a Cancer Drug as a Function of the Bond to the Gold Nanoparticle Surface VL - 0 KW - cancer KW - kinetics KW - nanotechnology AU - Cheng, Yu AU - Samia, Anna AU - Li, Jun AU - Kenney, Malcolm AU - Resnick, Andrew AU - Burda, Clemens PY - 2000/// UR - http://dx.doi.org/10.1021/la902390d ER -