Boundary lubrication in vivo Export

@article{Hills:00wd, abstract = {Evidence is reviewed for the concept that the body employs essentially the same lubrication system in many sites in the body where tissues slide over each other with such ease. This system consists of fluid adjacent to surfaces coated with an oligolamellar lining of surface-active phospholipid ( SAPL) acting as a back-up boundary lubricant wherever the fluid film fails to support the load---a likely event at physiological velocities. Particular attention is paid to the load-bearing joints, where the issue of identifying the vital active ingredient in synovial fluid is reviewed, coming down---perhaps predictably---in favour of SAPL. It is also explained how Lubricin and hyaluronic acid ( HA) could have `carrier' functions for the highly insoluble SAPL, while HA has good wetting properties needed to promote hydrodynamic lubrication of a very hydrophobic articular surface by an aqueous fluid wherever the load permits. In addition to friction and wear, release is included as another major role of boundary lubricants, especially relevant in environments where proteins are found, many having adhesive properties. The discussion is extended to a mention of the lubrication of prosthetic implants and to disease states where a deficiency of boundary lubricant is implicated, particular attention being paid to osteoarthritis.}, author = {Hills, B. A.}, citeulike-article-id = {2092021}, journal = {Proc. Instn. Mech. Engrs. H}, keywords = {bibtex-import, boundary, friction, implants, lubrication, osteoarthritis, phospholipid, prosthetic, surface-active, surfactants}, pages = {83--94}, posted-at = {2007-12-11 21:31:13}, priority = {0}, title = {Boundary lubrication {\it in vivo}}, volume = {214}, year = {2000} }

TY - JOUR ID - Hills:00wd L3 - citeulike-article-id:2092021 N2 - Evidence is reviewed for the concept that the body employs essentially the same lubrication system in many sites in the body where tissues slide over each other with such ease. This system consists of fluid adjacent to surfaces coated with an oligolamellar lining of surface-active phospholipid ( SAPL) acting as a back-up boundary lubricant wherever the fluid film fails to support the load---a likely event at physiological velocities. Particular attention is paid to the load-bearing joints, where the issue of identifying the vital active ingredient in synovial fluid is reviewed, coming down---perhaps predictably---in favour of SAPL. It is also explained how Lubricin and hyaluronic acid ( HA) could have `carrier' functions for the highly insoluble SAPL, while HA has good wetting properties needed to promote hydrodynamic lubrication of a very hydrophobic articular surface by an aqueous fluid wherever the load permits. In addition to friction and wear, release is included as another major role of boundary lubricants, especially relevant in environments where proteins are found, many having adhesive properties. The discussion is extended to a mention of the lubrication of prosthetic implants and to disease states where a deficiency of boundary lubricant is implicated, particular attention being paid to osteoarthritis. JF - Proc. Instn. Mech. Engrs. H EP - 94 TI - Boundary lubrication {\it in vivo} VL - 214 SP - 83 KW - bibtex-import KW - boundary KW - friction KW - implants KW - lubrication KW - osteoarthritis KW - phospholipid KW - prosthetic KW - surface-active KW - surfactants AU - Hills, BA PY - 2000/// ER -