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softsimu's heparin [4 articles]

Recent papers added to softsimu's library classified by the tag heparin. You can also see everyone's heparin.

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	Crystal Structure of the Sulfotransferase Domain of Human Heparan Sulfate N-Deacetylase/ N-Sulfotransferase 1 J. Biol. Chem., Vol. 274, No. 16. (16 April 1999), pp. 10673-10676. by Yoshimitsu Kakuta, Tatsuya Sueyoshi, Masahiko Negishi, Lars C. Pedersen posted to heparan heparin by softsimu on 2008-02-27 15:09:37 Abstract Copy My Attachments My Copy Abstract Heparan sulfate N-deacetylase/N-sulfotransferase (HSNST) catalyzes the first and obligatory step in the biosynthesis of heparan sulfates and heparin. The crystal structure of the sulfotransferase domain (NST1) of human HSNST-1 has been determined at 2.3-A resolution in a binary complex with 3'-phosphoadenosine 5'-phosphate (PAP). NST1 is approximately spherical with an open cleft, and consists of a single [alpha]/[beta] fold with a central five-stranded parallel [beta]-sheet and a three-stranded anti-parallel [beta]-sheet bearing an interstrand disulfide bond. The structural regions [alpha]1, [alpha]6, [beta]1, [beta]7, ...
	Proteoglycans: Structures and Interactions - Annual Review of Biochemistry, 60(1):443 - First Page Image posted to heparan heparin by softsimu on 2008-02-27 15:01:12 Copy My Attachments My Copy
	Crystal structures of NK1–heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor EMBO Journal (2001) posted to heparan heparin by softsimu on 2008-02-27 14:55:38 Copy My Attachments My Copy
	Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation Bioorganic & Medicinal Chemistry Letters, Vol. 17, No. 22. (15 November 2007), pp. 6321-6325. by Eun-Ang Raiber, James A. Wilkinson, Fabrizio Manetti, et al.Maurizio Botta, Jon Deakin, John Gallagher, Malcolm Lyon, Sylvie W. Ducki posted to heparan heparin by softsimu on 2008-02-27 14:53:45 Abstract Copy My Attachments My Copy Abstract The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF). ...

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