A high-density admixture map for disease gene discovery in african americans. Export

@article{citeulike:1269739, abstract = {Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with approximately 100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of validated markers known to have large frequency differences between Europeans and Africans. To create such a map, we screened through databases containing approximately 450000 single-nucleotide polymorphisms (SNPs) for which frequencies had been estimated in African and European population samples. We experimentally confirmed the frequencies of the most promising SNPs in a multiethnic panel of unrelated samples and identified 3011 as a MALD map (1.2 cM average spacing). We estimate that this map is approximately 70\% informative in differentiating African versus European origins of chromosomal segments. This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts. The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations.}, address = {Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA.}, author = {Smith, Michael W. and Patterson, Nick and Lautenberger, James A. and Truelove, Ann L. and McDonald, Gavin J. and Waliszewska, Alicja and Kessing, Bailey D. and Malasky, Michael J. and Scafe, Charles and Le, Ernest and De Jager, Philip L. and Mignault, Andre A. and Yi, Zeng and De The, Guy and Essex, Myron and Sankale, Jean-Louis L. and Moore, Jason H. and Poku, Kwabena and Phair, John P. and Goedert, James J. and Vlahov, David and Williams, Scott M. and Tishkoff, Sarah A. and Winkler, Cheryl A. and De La Vega, Francisco M. and Woodage, Trevor and Sninsky, John J. and Hafler, David A. and Altshuler, David and Gilbert, Dennis A. and O'Brien, Stephen J. and Reich, David}, citeulike-article-id = {1269739}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/420856}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15088270}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15088270}, doi = {10.1086/420856}, issn = {0002-9297}, journal = {American journal of human genetics}, keywords = {admixture, african, american, ancestry, informative, marker}, month = {May}, number = {5}, pages = {1001--1013}, posted-at = {2009-09-02 03:19:05}, priority = {2}, title = {A high-density admixture map for disease gene discovery in african americans.}, url = {http://dx.doi.org/10.1086/420856}, volume = {74}, year = {2004} }

TY - JOUR ID - citeulike:1269739 L3 - citeulike-article-id:1269739 N2 - Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with approximately 100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of validated markers known to have large frequency differences between Europeans and Africans. To create such a map, we screened through databases containing approximately 450000 single-nucleotide polymorphisms (SNPs) for which frequencies had been estimated in African and European population samples. We experimentally confirmed the frequencies of the most promising SNPs in a multiethnic panel of unrelated samples and identified 3011 as a MALD map (1.2 cM average spacing). We estimate that this map is approximately 70% informative in differentiating African versus European origins of chromosomal segments. This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts. The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations. IS - 5 JF - American journal of human genetics SN - 0002-9297 AD - Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA. EP - 1013 TI - A high-density admixture map for disease gene discovery in african americans. VL - 74 SP - 1001 KW - admixture KW - african KW - american KW - ancestry KW - informative KW - marker AU - Smith, Michael AU - Patterson, Nick AU - Lautenberger, James AU - Truelove, Ann AU - McDonald, Gavin AU - Waliszewska, Alicja AU - Kessing, Bailey AU - Malasky, Michael AU - Scafe, Charles AU - Le, Ernest AU - De Jager, Philip AU - Mignault, Andre AU - Yi, Zeng AU - De The, Guy AU - Essex, Myron AU - Sankale, Jean-Louis AU - Moore, Jason AU - Poku, Kwabena AU - Phair, John AU - Goedert, James AU - Vlahov, David AU - Williams, Scott AU - Tishkoff, Sarah AU - Winkler, Cheryl AU - De La Vega, Francisco AU - Woodage, Trevor AU - Sninsky, John AU - Hafler, David AU - Altshuler, David AU - Gilbert, Dennis AU - O'Brien, Stephen AU - Reich, David PY - 2004/05// UR - http://dx.doi.org/10.1086/420856 ER -