Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. Export

@article{citeulike:3610884, abstract = {BACKGROUND: The question of whether stress poses a risk for cancer progression has been difficult to answer. A randomized clinical trial tested the hypothesis that cancer patients coping with their recent diagnosis but receiving a psychologic intervention would have improved survival compared with patients who were only assessed. METHODS: A total of 227 patients who were surgically treated for regional breast cancer participated. Before beginning adjuvant cancer therapies, patients were assessed with psychologic and behavioral measures and had a health evaluation, and a 60-mL blood sample was drawn. Patients were randomized to Psychologic Intervention plus assessment or Assessment only study arms. The intervention was psychologist led; conducted in small groups; and included strategies to reduce stress, improve mood, alter health behaviors, and maintain adherence to cancer treatment and care. Earlier articles demonstrated that, compared with the Assessment arm, the Intervention arm improved across all of the latter secondary outcomes. Immunity was also enhanced. RESULTS: After a median of 11 years of follow-up, disease recurrence was reported to occur in 62 of 212 (29\%) women and death was reported for 54 of 227 (24\%) women. Using Cox proportional hazards analysis, multivariate comparison of survival was conducted. As predicted, patients in the Intervention arm were found to have a reduced risk of breast cancer recurrence (hazards ratio [HR] of 0.55; P = .034) and death from breast cancer (HR of 0.44; P = .016) compared with patients in the Assessment only arm. Follow-up analyses also demonstrated that Intervention patients had a reduced risk of death from all causes (HR of 0.51; P = .028). CONCLUSIONS: Psychologic interventions as delivered and studied here can improve survival.}, address = {Department of Psychology, Ohio State University, Columbus, Ohio; Comprehensive Cancer Center and Solove Research Institute, Ohio State University, Columbus, Ohio; Department of Surgery, College of Medicine, Ohio State University, Columbus, Ohio; Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, Ohio}, author = {Andersen, Barbara L. and Yang, Hae-Chung C. and Farrar, William B. and Golden-Kreutz, Deanna M. and Emery, Charles F. and Thornton, Lisa M. and Young, Donn C. and Carson, William E.}, citeulike-article-id = {3610884}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/cncr.23969}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19016270}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19016270}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121511810/ABSTRACT}, day = {15}, doi = {10.1002/cncr.23969}, issn = {0008-543X}, journal = {Cancer}, keywords = {breast, cancer, intervention, pyschological, stress, survival}, month = {December}, number = {12}, pages = {3450--3458}, posted-at = {2008-11-20 14:48:52}, priority = {2}, title = {Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial.}, url = {http://dx.doi.org/10.1002/cncr.23969}, volume = {113}, year = {2008} }

TY - JOUR ID - citeulike:3610884 L3 - citeulike-article-id:3610884 N2 - BACKGROUND: The question of whether stress poses a risk for cancer progression has been difficult to answer. A randomized clinical trial tested the hypothesis that cancer patients coping with their recent diagnosis but receiving a psychologic intervention would have improved survival compared with patients who were only assessed. METHODS: A total of 227 patients who were surgically treated for regional breast cancer participated. Before beginning adjuvant cancer therapies, patients were assessed with psychologic and behavioral measures and had a health evaluation, and a 60-mL blood sample was drawn. Patients were randomized to Psychologic Intervention plus assessment or Assessment only study arms. The intervention was psychologist led; conducted in small groups; and included strategies to reduce stress, improve mood, alter health behaviors, and maintain adherence to cancer treatment and care. Earlier articles demonstrated that, compared with the Assessment arm, the Intervention arm improved across all of the latter secondary outcomes. Immunity was also enhanced. RESULTS: After a median of 11 years of follow-up, disease recurrence was reported to occur in 62 of 212 (29%) women and death was reported for 54 of 227 (24%) women. Using Cox proportional hazards analysis, multivariate comparison of survival was conducted. As predicted, patients in the Intervention arm were found to have a reduced risk of breast cancer recurrence (hazards ratio [HR] of 0.55; P = .034) and death from breast cancer (HR of 0.44; P = .016) compared with patients in the Assessment only arm. Follow-up analyses also demonstrated that Intervention patients had a reduced risk of death from all causes (HR of 0.51; P = .028). CONCLUSIONS: Psychologic interventions as delivered and studied here can improve survival. IS - 12 JF - Cancer SN - 0008-543X AD - Department of Psychology, Ohio State University, Columbus, Ohio; Comprehensive Cancer Center and Solove Research Institute, Ohio State University, Columbus, Ohio; Department of Surgery, College of Medicine, Ohio State University, Columbus, Ohio; Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, Ohio EP - 3458 TI - Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. VL - 113 SP - 3450 KW - breast KW - cancer KW - intervention KW - pyschological KW - stress KW - survival AU - Andersen, Barbara AU - Yang, Hae-Chung AU - Farrar, William AU - Golden-Kreutz, Deanna AU - Emery, Charles AU - Thornton, Lisa AU - Young, Donn AU - Carson, William PY - 2008/12/15/ UR - http://dx.doi.org/10.1002/cncr.23969 ER -