Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis. Export

@article{citeulike:3816435, abstract = {Genetic variation in SIPA1, signal-induced proliferation-associated gene 1, has been proposed to be associated with aggressive breast tumor characteristics related to metastasis and worse prognosis in humans and rodents. To test this hypothesis, we genotyped 3 single nucleotide polymorphisms (SNP) located at -3092 (A<G, rs931127), exon 3-135 (C>T, rs3741378), and exon 14 + 14 (C>T, rs746429), and examined them in relation to breast cancer risk and overall survival, stratified by tumor characteristics in 2 independent case-control studies conducted in Poland (1,995 cases, 2,296 controls) and in Britain (2,142 cases, 2,257 controls). Vital status (n = 396 deaths) was available for 911 Polish and 1,919 British breast cancer cases with an average follow-up time of 5.5 years. Overall, we found no significant associations between genetic variants of SIPA1 SNPs and breast cancer risk (per allele odds ratios, 95\% confidence intervals (CI): rs931127-0.99, 0.93-1.06; rs3741378-1.03, 0.94-1.13; and, rs74642-0.98, 0.92-1.04). In both studies, SIPA1 polymorphisms were not related to overall mortality (per allele hazard ratios, 95\% CI: 1.02, 0.88-1.17; 0.90, 0.72-1.11; 1.04, 0.90-1.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival.}, author = {Gaudet, Mia M. and Hunter, Kent and Pharoah, Paul and Dunning, Alison M. and Driver, Kristy and Lissowska, Jolanta and Sherman, Mark and Peplonska, Beata and Brinton, Louise A. and Chanock, Stephen and Garcia-Closas, Montserrat}, citeulike-article-id = {3816435}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/ijc.23919}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19089925}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19089925}, day = {1}, doi = {10.1002/ijc.23919}, issn = {1097-0215}, journal = {International journal of cancer. Journal international du cancer}, keywords = {breast, cancer, polymorphis, sipa}, month = {April}, number = {7}, pages = {1716--1720}, posted-at = {2009-11-05 16:35:24}, priority = {2}, title = {Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis.}, url = {http://dx.doi.org/10.1002/ijc.23919}, volume = {124}, year = {2009} }

TY - JOUR ID - citeulike:3816435 L3 - citeulike-article-id:3816435 N2 - Genetic variation in SIPA1, signal-induced proliferation-associated gene 1, has been proposed to be associated with aggressive breast tumor characteristics related to metastasis and worse prognosis in humans and rodents. To test this hypothesis, we genotyped 3 single nucleotide polymorphisms (SNP) located at -3092 (A<G, rs931127), exon 3-135 (C>T, rs3741378), and exon 14 + 14 (C>T, rs746429), and examined them in relation to breast cancer risk and overall survival, stratified by tumor characteristics in 2 independent case-control studies conducted in Poland (1,995 cases, 2,296 controls) and in Britain (2,142 cases, 2,257 controls). Vital status (n = 396 deaths) was available for 911 Polish and 1,919 British breast cancer cases with an average follow-up time of 5.5 years. Overall, we found no significant associations between genetic variants of SIPA1 SNPs and breast cancer risk (per allele odds ratios, 95% confidence intervals (CI): rs931127-0.99, 0.93-1.06; rs3741378-1.03, 0.94-1.13; and, rs74642-0.98, 0.92-1.04). In both studies, SIPA1 polymorphisms were not related to overall mortality (per allele hazard ratios, 95% CI: 1.02, 0.88-1.17; 0.90, 0.72-1.11; 1.04, 0.90-1.21, respectively). Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival. IS - 7 JF - International journal of cancer. Journal international du cancer SN - 1097-0215 EP - 1720 TI - Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis. VL - 124 SP - 1716 KW - breast KW - cancer KW - polymorphis KW - sipa AU - Gaudet, Mia AU - Hunter, Kent AU - Pharoah, Paul AU - Dunning, Alison AU - Driver, Kristy AU - Lissowska, Jolanta AU - Sherman, Mark AU - Peplonska, Beata AU - Brinton, Louise AU - Chanock, Stephen AU - Garcia-Closas, Montserrat PY - 2009/04/01/ UR - http://dx.doi.org/10.1002/ijc.23919 ER -