Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. Export

@article{citeulike:4010200, abstract = {To provide a resource for assessing continental ancestry in a wide variety of genetic studies, we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs). The markers were chosen for informativeness, genome-wide distribution, and genotype reproducibility on two platforms (TaqMan assays and Illumina arrays). We analyzed genotyping data from 825 subjects with diverse ancestry, including European, East Asian, Amerindian, African, South Asian, Mexican, and Puerto Rican. A comprehensive set of 128 AIMs and subsets as small as 24 AIMs are shown to be useful tools for ascertaining the origin of subjects from particular continents, and to correct for population stratification in admixed population sample sets. Our findings provide general guidelines for the application of specific AIM subsets as a resource for wide application. We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations.}, author = {Kosoy, Roman and Nassir, Rami and Tian, Chao and White, Phoebe A. and Butler, Lesley M. and Silva, Gabriel and Kittles, Rick and Alarcon-Riquelme, Marta E. and Gregersen, Peter K. and Belmont, John W. and De La Vega, Francisco M. and Seldin, Michael F.}, citeulike-article-id = {4010200}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/humu.20822}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18683858}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18683858}, doi = {10.1002/humu.20822}, issn = {1098-1004}, journal = {Human mutation}, keywords = {admixture, aim, ancestry, informative, marker}, month = {January}, number = {1}, pages = {69--78}, posted-at = {2009-03-25 16:21:35}, priority = {2}, title = {Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America.}, url = {http://dx.doi.org/10.1002/humu.20822}, volume = {30}, year = {2009} }

TY - JOUR ID - citeulike:4010200 L3 - citeulike-article-id:4010200 N2 - To provide a resource for assessing continental ancestry in a wide variety of genetic studies, we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs). The markers were chosen for informativeness, genome-wide distribution, and genotype reproducibility on two platforms (TaqMan assays and Illumina arrays). We analyzed genotyping data from 825 subjects with diverse ancestry, including European, East Asian, Amerindian, African, South Asian, Mexican, and Puerto Rican. A comprehensive set of 128 AIMs and subsets as small as 24 AIMs are shown to be useful tools for ascertaining the origin of subjects from particular continents, and to correct for population stratification in admixed population sample sets. Our findings provide general guidelines for the application of specific AIM subsets as a resource for wide application. We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations. IS - 1 JF - Human mutation SN - 1098-1004 EP - 78 TI - Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. VL - 30 SP - 69 KW - admixture KW - aim KW - ancestry KW - informative KW - marker AU - Kosoy, Roman AU - Nassir, Rami AU - Tian, Chao AU - White, Phoebe AU - Butler, Lesley AU - Silva, Gabriel AU - Kittles, Rick AU - Alarcon-Riquelme, Marta AU - Gregersen, Peter AU - Belmont, John AU - De La Vega, Francisco AU - Seldin, Michael PY - 2009/01// UR - http://dx.doi.org/10.1002/humu.20822 ER -