Acute Chemotherapy-Related Toxicity Is Not Increased in BRCA1 and BRCA2 Mutation Carriers Treated for Breast Cancer in the United Kingdom Export

@article{citeulike:4597040, abstract = {Purpose: To evaluate acute toxicity induced by chemotherapy for breast cancer in a retrospective study of 62 BRCA1/2 mutation carriers matched 1:1 with women who had treatment for sporadic disease in the United Kingdom between 1983 and 2003. Experimental Design: All participants were interviewed by one of two researchers using standardized questionnaires, and their medical records were reviewed by one research nurse. The two main regimens received were cyclophosphamide, methotrexate, and fluorouracil and fluorouracil, epirubicin, and cyclophosphamide. The proportion of cases and controls receiving anthracycline-based treatment was equivalent, but fewer BRCA1 cases received this treatment than did BRCA2 mutation carriers. Toxicity was documented using the Eastern Cooperative Oncology Group Common Toxicity Criteria for hematologic, infective, and gastrointestinal toxicities. No increase in toxicity was seen in BRCA1/2 mutation carriers. Results: The only significant difference was that neutropenia was less evident in BRCA2 mutation carriers than in either BRCA1 mutation carriers or controls. As a result, there was no requirement for dose reduction among BRCA2 mutation carriers, in contrast to 10 of 39 BRCA1 carriers and 16 of 62 controls (P = 0.02). Conclusions: This result has implications for therapy and indicates that women with mutations in BRCA1 and BRCA2 may be given the same doses of chemotherapy as noncarriers. 10.1158/1078-0432.CCR-06-1246}, author = {Shanley, Susan and Mcreynolds, Kate and Ardern-Jones, Audrey and Ahern, Roger and Fernando, Indrajit and Yarnold, John and Evans, Gareth and Eccles, Diana and Hodgson, Shirley and Ashley, Sue and Ashcroft, Linda and Tutt, Andrew and Bancroft, Elizabeth and Short, Susan and Smith, Ian and Gui, Gerald and The and Barr, Lester and Baildam, Andrew and Howell, Anthony and Royle, Gavin and Pierce, Lori and Easton, Douglas and Eeles, Rosalind}, citeulike-article-id = {4597040}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1078-0432.CCR-06-1246}, citeulike-linkout-1 = {http://clincancerres.aacrjournals.org/cgi/content/abstract/12/23/7033}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17145825}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17145825}, day = {1}, doi = {10.1158/1078-0432.CCR-06-1246}, journal = {Clin Cancer Res}, keywords = {brca, breast, cancer, toxicity}, month = {December}, number = {23}, pages = {7033--7038}, posted-at = {2009-05-22 14:36:27}, priority = {2}, title = {Acute Chemotherapy-Related Toxicity Is Not Increased in BRCA1 and BRCA2 Mutation Carriers Treated for Breast Cancer in the United Kingdom}, url = {http://dx.doi.org/10.1158/1078-0432.CCR-06-1246}, volume = {12}, year = {2006} }

TY - JOUR ID - citeulike:4597040 L3 - citeulike-article-id:4597040 N2 - Purpose: To evaluate acute toxicity induced by chemotherapy for breast cancer in a retrospective study of 62 BRCA1/2 mutation carriers matched 1:1 with women who had treatment for sporadic disease in the United Kingdom between 1983 and 2003. Experimental Design: All participants were interviewed by one of two researchers using standardized questionnaires, and their medical records were reviewed by one research nurse. The two main regimens received were cyclophosphamide, methotrexate, and fluorouracil and fluorouracil, epirubicin, and cyclophosphamide. The proportion of cases and controls receiving anthracycline-based treatment was equivalent, but fewer BRCA1 cases received this treatment than did BRCA2 mutation carriers. Toxicity was documented using the Eastern Cooperative Oncology Group Common Toxicity Criteria for hematologic, infective, and gastrointestinal toxicities. No increase in toxicity was seen in BRCA1/2 mutation carriers. Results: The only significant difference was that neutropenia was less evident in BRCA2 mutation carriers than in either BRCA1 mutation carriers or controls. As a result, there was no requirement for dose reduction among BRCA2 mutation carriers, in contrast to 10 of 39 BRCA1 carriers and 16 of 62 controls (P = 0.02). Conclusions: This result has implications for therapy and indicates that women with mutations in BRCA1 and BRCA2 may be given the same doses of chemotherapy as noncarriers. 10.1158/1078-0432.CCR-06-1246 IS - 23 JF - Clin Cancer Res EP - 7038 TI - Acute Chemotherapy-Related Toxicity Is Not Increased in BRCA1 and BRCA2 Mutation Carriers Treated for Breast Cancer in the United Kingdom VL - 12 SP - 7033 KW - brca KW - breast KW - cancer KW - toxicity AU - Shanley, Susan AU - Mcreynolds, Kate AU - Ardern-Jones, Audrey AU - Ahern, Roger AU - Fernando, Indrajit AU - Yarnold, John AU - Evans, Gareth AU - Eccles, Diana AU - Hodgson, Shirley AU - Ashley, Sue AU - Ashcroft, Linda AU - Tutt, Andrew AU - Bancroft, Elizabeth AU - Short, Susan AU - Smith, Ian AU - Gui, Gerald AU - The AU - Barr, Lester AU - Baildam, Andrew AU - Howell, Anthony AU - Royle, Gavin AU - Pierce, Lori AU - Easton, Douglas AU - Eeles, Rosalind PY - 2006/12/01/ UR - http://dx.doi.org/10.1158/1078-0432.CCR-06-1246 ER -