Late Toxicity Is Not Increased in BRCA1/BRCA2 Mutation Carriers Undergoing Breast Radiotherapy in the United Kingdom Export

@article{citeulike:4597136, abstract = {Purpose: To undertake the first substantial clinical study of breast radiotherapy toxicity in BRCA1 and BRCA2 mutation carriers in the United Kingdom. Experimental Design: Acute and late radiation effects were evaluated in a retrospective study of 55 BRCA1 and BRCA2 mutation carriers treated with radiotherapy for breast cancer at four centers between 1983 and 2002. Individual matching with controls who had sporadic breast cancer was undertaken for age at diagnosis, time since completion of radiation, and treatment variables. Detailed assessments were undertaken by one examiner. Median follow-up was 6.75 years for carriers and 7.75 years for controls. Rates of late events (rib fractures, lung fibrosis, necrosis of soft tissue/bone, and pericarditis) as well as LENT-SOMA scores and clinical photography scores of breast size, shape, and skin telangiectasia were the primary end points. Results: No increase in clinically significant late toxicity was seen in the mutation carriers. Conclusions: These data add substantial weight to the evidence that the outcomes in the treated breast from radiotherapy in women with BRCA1 or BRCA2 mutations are comparable with those in women with sporadic breast cancer. 10.1158/1078-0432.CCR-06-1244}, author = {Shanley, Susan and Mcreynolds, Kate and Ardern-Jones, Audrey and Ahern, Roger and Fernando, Indrajit and Yarnold, John and Evans, Gareth and Eccles, Diana and Hodgson, Shirley and Ashley, Sue and Ashcroft, Linda and Tutt, Andrew and Bancroft, Elizabeth and Short, Susan and Gui, Gerald and The and Barr, Lester and Baildam, Andrew and Howell, Anthony and Royle, Gavin and Pierce, Lori and Easton, Douglas and Eeles, Rosalind}, citeulike-article-id = {4597136}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1078-0432.CCR-06-1244}, citeulike-linkout-1 = {http://clincancerres.aacrjournals.org/cgi/content/abstract/12/23/7025}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17145824}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17145824}, day = {1}, doi = {10.1158/1078-0432.CCR-06-1244}, journal = {Clin Cancer Res}, keywords = {brca, radiotherapy, toxicity}, month = {December}, number = {23}, pages = {7025--7032}, posted-at = {2009-05-22 14:50:09}, priority = {2}, title = {Late Toxicity Is Not Increased in BRCA1/BRCA2 Mutation Carriers Undergoing Breast Radiotherapy in the United Kingdom}, url = {http://dx.doi.org/10.1158/1078-0432.CCR-06-1244}, volume = {12}, year = {2006} }

TY - JOUR ID - citeulike:4597136 L3 - citeulike-article-id:4597136 N2 - Purpose: To undertake the first substantial clinical study of breast radiotherapy toxicity in BRCA1 and BRCA2 mutation carriers in the United Kingdom. Experimental Design: Acute and late radiation effects were evaluated in a retrospective study of 55 BRCA1 and BRCA2 mutation carriers treated with radiotherapy for breast cancer at four centers between 1983 and 2002. Individual matching with controls who had sporadic breast cancer was undertaken for age at diagnosis, time since completion of radiation, and treatment variables. Detailed assessments were undertaken by one examiner. Median follow-up was 6.75 years for carriers and 7.75 years for controls. Rates of late events (rib fractures, lung fibrosis, necrosis of soft tissue/bone, and pericarditis) as well as LENT-SOMA scores and clinical photography scores of breast size, shape, and skin telangiectasia were the primary end points. Results: No increase in clinically significant late toxicity was seen in the mutation carriers. Conclusions: These data add substantial weight to the evidence that the outcomes in the treated breast from radiotherapy in women with BRCA1 or BRCA2 mutations are comparable with those in women with sporadic breast cancer. 10.1158/1078-0432.CCR-06-1244 IS - 23 JF - Clin Cancer Res EP - 7032 TI - Late Toxicity Is Not Increased in BRCA1/BRCA2 Mutation Carriers Undergoing Breast Radiotherapy in the United Kingdom VL - 12 SP - 7025 KW - brca KW - radiotherapy KW - toxicity AU - Shanley, Susan AU - Mcreynolds, Kate AU - Ardern-Jones, Audrey AU - Ahern, Roger AU - Fernando, Indrajit AU - Yarnold, John AU - Evans, Gareth AU - Eccles, Diana AU - Hodgson, Shirley AU - Ashley, Sue AU - Ashcroft, Linda AU - Tutt, Andrew AU - Bancroft, Elizabeth AU - Short, Susan AU - Gui, Gerald AU - The AU - Barr, Lester AU - Baildam, Andrew AU - Howell, Anthony AU - Royle, Gavin AU - Pierce, Lori AU - Easton, Douglas AU - Eeles, Rosalind PY - 2006/12/01/ UR - http://dx.doi.org/10.1158/1078-0432.CCR-06-1244 ER -