Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer Export

@article{citeulike:5658486, abstract = {Purpose: Compared with white women, black women experience a disproportionate burden of aggressive breast cancer for reasons that remain unknown and understudied. In the first study of its kind, we determined the distribution of molecular subtypes of invasive breast tumors in indigenous black women in West Africa.Patients and Methods: The study comprised 507 patients diagnosed with breast cancer between 1996 and 2007 at six geographic regions in Nigeria and Senegal. Formalin-fixed and paraffin-embedded sections were constructed into tissue microarrays and immunostained with 15 antibodies. Five molecular subtypes were determined, and hierarchical cluster analysis was conducted to explore subgroups for unclassified cases.Results: The mean ({+/-} standard deviation) age of 378 patients in the first cohort was 44.8 {+/-} 11.8 years, with the majority of women presenting with large (4.4 {+/-} 2.0 cm) high-grade tumors (83\%) in advanced stages (72\% node positive). The proportions of estrogen receptor (ER) -positive, progesterone receptor-positive, and human epidermal growth factor receptor 2 (HER2) -positive tumors were 24\%, 20\%, and 17\%, respectively. Triple negativity for these markers was predominant, including basal-like (27\%) and unclassified subtype (28\%). Other subtypes were luminal A (27\%), luminal B (2\%), and HER2 positive/ER negative (15\%). The findings were replicated in the second cohort of 129 patients. The unclassified cases could be grouped into a bad prognosis branch, with expression of vascular endothelial growth factor, B-cell lymphoma extra-large protein, and Cyclin E, and a good prognosis branch, with expression of B-cell lymphoma protein 2 and Cyclin D1.Conclusion: These findings underscore the urgent need for research into the etiology and treatment of the aggressive molecular subtypes that disproportionately affect young women in the African diaspora. 10.1200/JCO.2008.19.6873}, author = {Huo, Dezheng and Ikpatt, Francis and Khramtsov, Andrey and Dangou, Jean-Marie and Nanda, Rita and Dignam, James and Zhang, Bifeng and Grushko, Tatyana and Zhang, Chunling and Oluwasola, Olayiwola and Malaka, David and Malami, Sani and Odetunde, Abayomi and Adeoye, Adewumi O. and Iyare, Festus and Falusi, Adeyinka and Perou, Charles M. and Olopade, Olufunmilayo I.}, citeulike-article-id = {5658486}, citeulike-linkout-0 = {http://dx.doi.org/10.1200/JCO.2008.19.6873}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19704069}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19704069}, day = {24}, doi = {10.1200/JCO.2008.19.6873}, journal = {J Clin Oncol}, keywords = {african, breast, cancer, disparity, negative, racial, triple}, month = {August}, pages = {JCO.2008.19.6873+}, posted-at = {2009-08-27 18:50:15}, priority = {2}, title = {Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer}, url = {http://dx.doi.org/10.1200/JCO.2008.19.6873}, year = {2009} }

TY - JOUR ID - citeulike:5658486 L3 - citeulike-article-id:5658486 N2 - Purpose: Compared with white women, black women experience a disproportionate burden of aggressive breast cancer for reasons that remain unknown and understudied. In the first study of its kind, we determined the distribution of molecular subtypes of invasive breast tumors in indigenous black women in West Africa.Patients and Methods: The study comprised 507 patients diagnosed with breast cancer between 1996 and 2007 at six geographic regions in Nigeria and Senegal. Formalin-fixed and paraffin-embedded sections were constructed into tissue microarrays and immunostained with 15 antibodies. Five molecular subtypes were determined, and hierarchical cluster analysis was conducted to explore subgroups for unclassified cases.Results: The mean ({+/-} standard deviation) age of 378 patients in the first cohort was 44.8 {+/-} 11.8 years, with the majority of women presenting with large (4.4 {+/-} 2.0 cm) high-grade tumors (83%) in advanced stages (72% node positive). The proportions of estrogen receptor (ER) -positive, progesterone receptor-positive, and human epidermal growth factor receptor 2 (HER2) -positive tumors were 24%, 20%, and 17%, respectively. Triple negativity for these markers was predominant, including basal-like (27%) and unclassified subtype (28%). Other subtypes were luminal A (27%), luminal B (2%), and HER2 positive/ER negative (15%). The findings were replicated in the second cohort of 129 patients. The unclassified cases could be grouped into a bad prognosis branch, with expression of vascular endothelial growth factor, B-cell lymphoma extra-large protein, and Cyclin E, and a good prognosis branch, with expression of B-cell lymphoma protein 2 and Cyclin D1.Conclusion: These findings underscore the urgent need for research into the etiology and treatment of the aggressive molecular subtypes that disproportionately affect young women in the African diaspora. 10.1200/JCO.2008.19.6873 JF - J Clin Oncol TI - Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer SP - JCO.2008.19.6873 KW - african KW - breast KW - cancer KW - disparity KW - negative KW - racial KW - triple AU - Huo, Dezheng AU - Ikpatt, Francis AU - Khramtsov, Andrey AU - Dangou, Jean-Marie AU - Nanda, Rita AU - Dignam, James AU - Zhang, Bifeng AU - Grushko, Tatyana AU - Zhang, Chunling AU - Oluwasola, Olayiwola AU - Malaka, David AU - Malami, Sani AU - Odetunde, Abayomi AU - Adeoye, Adewumi AU - Iyare, Festus AU - Falusi, Adeyinka AU - Perou, Charles AU - Olopade, Olufunmilayo PY - 2009/08/24/ UR - http://dx.doi.org/10.1200/JCO.2008.19.6873 ER -