Relationship Between Potentially Modifiable Lifestyle Factors and Risk of Second Primary Contralateral Breast Cancer Among Women Diagnosed With Estrogen Receptor-Positive Invasive Breast Cancer Export

@article{citeulike:5808639, abstract = {PurposeAn outcome of considerable concern among breast cancer survivors is the development of second primary breast cancer. However, evidence regarding how potentially modifiable lifestyle factors modulate second breast cancer risk is limited. We evaluated the relationships between obesity, alcohol consumption, and smoking on risk of second primary invasive contralateral breast cancer among breast cancer survivors. MethodsUtilizing a population-based nested case-control study design, we enrolled 365 patients diagnosed with an estrogen receptor-positive (ER+) first primary invasive breast cancer and a second primary contralateral invasive breast cancer, and 726 matched controls diagnosed with only an ER+ first primary invasive breast cancer. Obesity, alcohol use, and smoking data were ascertained from medical record reviews and participant interviews. Using conditional logistic regression we evaluated associations between these three exposures and second primary contralateral breast cancer risk. ResultsObesity, consumption of [\≥] 7 alcoholic beverages per week, and current smoking were all positively related to risk of contralateral breast cancer (odds ratio [OR], 1.4; 95\% CI, 1.0 to 2.1; OR, 1.9; 95\% CI, 1.1 to 3.2; and OR, 2.2; 95\% CI, 1.2 to 4.0, respectively). Compared with women who consumed fewer than seven alcoholic beverages per week and were never or former smokers, women who consumed [\≥] 7 drinks per week and were current smokers had a 7.2-fold (95\% CI, 1.9 to 26.5) elevated risk of contralateral breast cancer. ConclusionOur population-based study adds to the limited available literature and suggests that obesity, smoking, and alcohol consumption influence contralateral breast cancer risk, affording breast cancer survivors three means of potentially reducing this risk. 10.1200/JCO.2009.23.1597}, author = {Li, Christopher I. and Daling, Janet R. and Porter, Peggy L. and Tang, Mei-Tzu C. and Malone, Kathleen E.}, booktitle = {J Clin Oncol}, citeulike-article-id = {5808639}, citeulike-linkout-0 = {http://dx.doi.org/10.1200/JCO.2009.23.1597}, citeulike-linkout-1 = {http://jco.ascopubs.org/content/JCO.2009.23.1597v1/.abstract}, citeulike-linkout-2 = {http://jco.ascopubs.org/content/JCO.2009.23.1597v1/.full.pdf}, citeulike-linkout-3 = {http://jco.ascopubs.org/cgi/content/abstract/27/32/5312}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19738113}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19738113}, day = {10}, doi = {10.1200/JCO.2009.23.1597}, issn = {1527-7755}, journal = {J Clin Oncol}, keywords = {alcohol, breast, cancer, contralateral, obesity, primary, second, smoking}, month = {November}, number = {32}, pages = {5312--5318}, posted-at = {2009-10-28 19:00:56}, priority = {2}, title = {Relationship Between Potentially Modifiable Lifestyle Factors and Risk of Second Primary Contralateral Breast Cancer Among Women Diagnosed With Estrogen Receptor-Positive Invasive Breast Cancer}, url = {http://dx.doi.org/10.1200/JCO.2009.23.1597}, volume = {27}, year = {2009} }

TY - JOUR ID - citeulike:5808639 L3 - citeulike-article-id:5808639 N2 - PurposeAn outcome of considerable concern among breast cancer survivors is the development of second primary breast cancer. However, evidence regarding how potentially modifiable lifestyle factors modulate second breast cancer risk is limited. We evaluated the relationships between obesity, alcohol consumption, and smoking on risk of second primary invasive contralateral breast cancer among breast cancer survivors. MethodsUtilizing a population-based nested case-control study design, we enrolled 365 patients diagnosed with an estrogen receptor-positive (ER+) first primary invasive breast cancer and a second primary contralateral invasive breast cancer, and 726 matched controls diagnosed with only an ER+ first primary invasive breast cancer. Obesity, alcohol use, and smoking data were ascertained from medical record reviews and participant interviews. Using conditional logistic regression we evaluated associations between these three exposures and second primary contralateral breast cancer risk. ResultsObesity, consumption of [≥] 7 alcoholic beverages per week, and current smoking were all positively related to risk of contralateral breast cancer (odds ratio [OR], 1.4; 95% CI, 1.0 to 2.1; OR, 1.9; 95% CI, 1.1 to 3.2; and OR, 2.2; 95% CI, 1.2 to 4.0, respectively). Compared with women who consumed fewer than seven alcoholic beverages per week and were never or former smokers, women who consumed [≥] 7 drinks per week and were current smokers had a 7.2-fold (95% CI, 1.9 to 26.5) elevated risk of contralateral breast cancer. ConclusionOur population-based study adds to the limited available literature and suggests that obesity, smoking, and alcohol consumption influence contralateral breast cancer risk, affording breast cancer survivors three means of potentially reducing this risk. 10.1200/JCO.2009.23.1597 IS - 32 JF - J Clin Oncol SN - 1527-7755 EP - 5318 TI - Relationship Between Potentially Modifiable Lifestyle Factors and Risk of Second Primary Contralateral Breast Cancer Among Women Diagnosed With Estrogen Receptor-Positive Invasive Breast Cancer VL - 27 T2 - J Clin Oncol SP - 5312 KW - alcohol KW - breast KW - cancer KW - contralateral KW - obesity KW - primary KW - second KW - smoking AU - Li, Christopher AU - Daling, Janet AU - Porter, Peggy AU - Tang, Mei-Tzu AU - Malone, Kathleen PY - 2009/11/10/ UR - http://dx.doi.org/10.1200/JCO.2009.23.1597 ER -