Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies Export

@article{citeulike:5908343, abstract = {Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 10-8), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.}, booktitle = {Nat Genet}, citeulike-article-id = {5908343}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.446}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.446}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19801982}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19801982}, day = {04}, doi = {10.1038/ng.446}, issn = {1061-4036}, journal = {Nature Genetics}, keywords = {bmd, bone, gwas}, month = {October}, number = {11}, pages = {1199--1206}, posted-at = {2009-11-02 16:04:31}, priority = {2}, publisher = {Nature Publishing Group}, title = {Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies}, url = {http://dx.doi.org/10.1038/ng.446}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:5908343 L3 - citeulike-article-id:5908343 N2 - Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 10-8), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q21.1 (MEPE), 5q14 (MEF2C), 7p14 (STARD3NL), 7q21.3 (FLJ42280), 11p11.2 (LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1). The meta-analysis also confirmed at GWS level seven known BMD loci on 1p36 (ZBTB40), 6q25 (ESR1), 8q24 (TNFRSF11B), 11q13.4 (LRP5), 12q13 (SP7), 13q14 (TNFSF11) and 18q21 (TNFRSF11A). The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD. IS - 11 JF - Nature Genetics SN - 1061-4036 EP - 1206 TI - Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies PB - Nature Publishing Group VL - 41 T2 - Nat Genet SP - 1199 KW - bmd KW - bone KW - gwas PY - 2009/10/04/ UR - http://dx.doi.org/10.1038/ng.446 ER -