Germ line polymorphism in metastatic progression. Export

@article{citeulike:6075176, abstract = {Somatic genetic analysis of tumors and metastases has yielded a plethora of information regarding genes associated with cancer progression. However, somatic alterations in tumor cells are only one source of variability. Genetic polymorphism may also play a significant role in person-to-person variability in metastasis frequency, raising the intriguing possibility that some individuals could be predisposed to secondary tumor development. The identification and characterization of these polymorphisms may have significant implications for the development of tailored treatment or prevention of recurrent disease.}, author = {Hunter, Kent W. and Crawford, Nigel P.}, citeulike-article-id = {6075176}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-05-3705}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16452174}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16452174}, day = {1}, doi = {10.1158/0008-5472.CAN-05-3705}, issn = {0008-5472}, journal = {Cancer research}, keywords = {breast, cancer, germline, metastasis, polymorphism, review}, month = {February}, number = {3}, pages = {1251--1254}, posted-at = {2009-11-05 16:35:35}, priority = {2}, title = {Germ line polymorphism in metastatic progression.}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-05-3705}, volume = {66}, year = {2006} }

TY - JOUR ID - citeulike:6075176 L3 - citeulike-article-id:6075176 N2 - Somatic genetic analysis of tumors and metastases has yielded a plethora of information regarding genes associated with cancer progression. However, somatic alterations in tumor cells are only one source of variability. Genetic polymorphism may also play a significant role in person-to-person variability in metastasis frequency, raising the intriguing possibility that some individuals could be predisposed to secondary tumor development. The identification and characterization of these polymorphisms may have significant implications for the development of tailored treatment or prevention of recurrent disease. IS - 3 JF - Cancer research SN - 0008-5472 EP - 1254 TI - Germ line polymorphism in metastatic progression. VL - 66 SP - 1251 KW - breast KW - cancer KW - germline KW - metastasis KW - polymorphism KW - review AU - Hunter, Kent AU - Crawford, Nigel PY - 2006/02/01/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-05-3705 ER -