An admixture scan in 1,484 African American women with breast cancer. Export

@article{citeulike:6083148, abstract = {African American women with breast cancer present more commonly with aggressive tumors that do not express the estrogen receptor (ER) and progesterone receptor (PR) compared with European American women. Whether this disparity is the result of inherited factors has not been established. We did an admixture-based genome-wide scan to search for risk alleles for breast cancer that are highly differentiated in frequency between African American and European American women, and may contribute to specific breast cancer phenotypes, such as ER-negative (ER-) disease. African American women with invasive breast cancer (n = 1,484) were pooled from six population-based studies and typed at approximately 1,500 ancestry-informative markers. We investigated global genetic ancestry and did a whole genome admixture scan searching for breast cancer-predisposing loci in association with disease phenotypes. We found a significant difference in ancestry between ER+PR+ and ER-PR- women, with higher European ancestry among ER+PR+ individuals, after controlling for possible confounders (odds ratios for a 0 to 1 change in European ancestry proportion, 2.84; 95\% confidence interval, 1.13-7.14; P = 0.026). Women with localized tumors had higher European ancestry than women with non-localized tumors (odds ratios, 2.65; 95\% confidence interval, 1.11-6.35; P = 0.029). No genome-wide statistically significant associations were observed between European or African ancestry at any specific locus and breast cancer, or in analyses stratified by ER/PR status, stage, or grade. In summary, in African American women, genetic ancestry is associated with ER/PR status and disease stage. However, we found little evidence that genetic ancestry at any one region contributes significantly to breast cancer risk or hormone receptor status.}, author = {Fejerman, Laura and Haiman, Christopher A. and Reich, David and Tandon, Arti and Deo, Rahul C. and John, Esther M. and Ingles, Sue A. and Ambrosone, Christine B. and Bovbjerg, Dana Howard H. and Jandorf, Lina H. and Davis, Warren and Ciupak, Gregory and Whittemore, Alice S. and Press, Michael F. and Ursin, Giske and Bernstein, Leslie and Huntsman, Scott and Henderson, Brian E. and Ziv, Elad and Freedman, Matthew L.}, citeulike-article-id = {6083148}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/1055-9965.EPI-09-0464}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19843668}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19843668}, day = {20}, doi = {10.1158/1055-9965.EPI-09-0464}, issn = {1538-7755}, journal = {Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, keywords = {admixture, african, american, breast, cancer, disparity, genetic, racial}, month = {November}, number = {11}, pages = {3110--3117}, posted-at = {2009-11-07 17:38:24}, priority = {2}, title = {An admixture scan in 1,484 African American women with breast cancer.}, url = {http://dx.doi.org/10.1158/1055-9965.EPI-09-0464}, volume = {18}, year = {2009} }

TY - JOUR ID - citeulike:6083148 L3 - citeulike-article-id:6083148 N2 - African American women with breast cancer present more commonly with aggressive tumors that do not express the estrogen receptor (ER) and progesterone receptor (PR) compared with European American women. Whether this disparity is the result of inherited factors has not been established. We did an admixture-based genome-wide scan to search for risk alleles for breast cancer that are highly differentiated in frequency between African American and European American women, and may contribute to specific breast cancer phenotypes, such as ER-negative (ER-) disease. African American women with invasive breast cancer (n = 1,484) were pooled from six population-based studies and typed at approximately 1,500 ancestry-informative markers. We investigated global genetic ancestry and did a whole genome admixture scan searching for breast cancer-predisposing loci in association with disease phenotypes. We found a significant difference in ancestry between ER+PR+ and ER-PR- women, with higher European ancestry among ER+PR+ individuals, after controlling for possible confounders (odds ratios for a 0 to 1 change in European ancestry proportion, 2.84; 95% confidence interval, 1.13-7.14; P = 0.026). Women with localized tumors had higher European ancestry than women with non-localized tumors (odds ratios, 2.65; 95% confidence interval, 1.11-6.35; P = 0.029). No genome-wide statistically significant associations were observed between European or African ancestry at any specific locus and breast cancer, or in analyses stratified by ER/PR status, stage, or grade. In summary, in African American women, genetic ancestry is associated with ER/PR status and disease stage. However, we found little evidence that genetic ancestry at any one region contributes significantly to breast cancer risk or hormone receptor status. IS - 11 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology SN - 1538-7755 EP - 3117 TI - An admixture scan in 1,484 African American women with breast cancer. VL - 18 SP - 3110 KW - admixture KW - african KW - american KW - breast KW - cancer KW - disparity KW - genetic KW - racial AU - Fejerman, Laura AU - Haiman, Christopher AU - Reich, David AU - Tandon, Arti AU - Deo, Rahul AU - John, Esther AU - Ingles, Sue AU - Ambrosone, Christine AU - Bovbjerg, Dana Howard AU - Jandorf, Lina AU - Davis, Warren AU - Ciupak, Gregory AU - Whittemore, Alice AU - Press, Michael AU - Ursin, Giske AU - Bernstein, Leslie AU - Huntsman, Scott AU - Henderson, Brian AU - Ziv, Elad AU - Freedman, Matthew PY - 2009/11/20/ UR - http://dx.doi.org/10.1158/1055-9965.EPI-09-0464 ER -