Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. Export

@article{citeulike:6083177, abstract = {microRNAs (miRNAs) are an abundant class of small noncoding RNA molecules thought to be involved in biological functions, including embryonic development, chromosome architecture, cell proliferation and apoptosis. We hypothesized that common variants in the miRNAs are associated with risk of coal workers' pneumoconiosis (CWP). In a case-control study of 496 CWP patients and 513 control subjects frequency matched by exposure years and work types, we genotyped four single-nucleotide polymorphisms (SNPs) (rs2910164, rs2292832, rs11614913 and rs3746444) in pre-miRNAs (miR-146a, miR-149, miR-196a2 and miR-499) and assessed the associations with risk of CWP. A significantly increased risk of CWP was found for the miR-149 rs2292832 TT genotype (odds ratio (OR), 1.31; 95\% confidence interval (CI), 1.01-1.69), compared with the CT/CC genotypes, and this increased risk was evident among subgroups of those aged >/=68 years (OR=1.52, 95\% CI=1.03-2.25), dust exposure >/=26 years (OR=1.42, 95\% CI=1.04-1.93) and ever smokers (OR=1.48, 95\% CI=1.00-2.20). Furthermore, a significant association was observed between the genotypes and patients with stages II and III (OR=1.50, 95\% CI=1.05-2.14 for stage II, and OR=3.33, 95\% CI=1.67-6.65 for stage III). These results suggest that miR-149 rs2292832 polymorphism is involved in susceptibility to developing CWP.Journal of Human Genetics advance online publication, 30 October 2009; doi:10.1038/jhg.2009.112.}, author = {Wang, Meilin and Ye, Yang and Qian, Haiyang and Song, Zhifang and Jia, Xiaomin and Zhang, Zhengdong and Zhou, Jianwei and Ni, Chunhui}, citeulike-article-id = {6083177}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/jhg.2009.112}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19881472}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19881472}, day = {30}, doi = {10.1038/jhg.2009.112}, issn = {1435-232X}, journal = {Journal of human genetics}, keywords = {microrna, mirna, polymorphism, pre-microrna, snp}, month = {October}, posted-at = {2009-11-07 17:56:34}, priority = {2}, title = {Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis.}, url = {http://dx.doi.org/10.1038/jhg.2009.112}, year = {2009} }

TY - JOUR ID - citeulike:6083177 L3 - citeulike-article-id:6083177 N2 - microRNAs (miRNAs) are an abundant class of small noncoding RNA molecules thought to be involved in biological functions, including embryonic development, chromosome architecture, cell proliferation and apoptosis. We hypothesized that common variants in the miRNAs are associated with risk of coal workers' pneumoconiosis (CWP). In a case-control study of 496 CWP patients and 513 control subjects frequency matched by exposure years and work types, we genotyped four single-nucleotide polymorphisms (SNPs) (rs2910164, rs2292832, rs11614913 and rs3746444) in pre-miRNAs (miR-146a, miR-149, miR-196a2 and miR-499) and assessed the associations with risk of CWP. A significantly increased risk of CWP was found for the miR-149 rs2292832 TT genotype (odds ratio (OR), 1.31; 95% confidence interval (CI), 1.01-1.69), compared with the CT/CC genotypes, and this increased risk was evident among subgroups of those aged >/=68 years (OR=1.52, 95% CI=1.03-2.25), dust exposure >/=26 years (OR=1.42, 95% CI=1.04-1.93) and ever smokers (OR=1.48, 95% CI=1.00-2.20). Furthermore, a significant association was observed between the genotypes and patients with stages II and III (OR=1.50, 95% CI=1.05-2.14 for stage II, and OR=3.33, 95% CI=1.67-6.65 for stage III). These results suggest that miR-149 rs2292832 polymorphism is involved in susceptibility to developing CWP.Journal of Human Genetics advance online publication, 30 October 2009; doi:10.1038/jhg.2009.112. JF - Journal of human genetics SN - 1435-232X TI - Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis. KW - microrna KW - mirna KW - polymorphism KW - pre-microrna KW - snp AU - Wang, Meilin AU - Ye, Yang AU - Qian, Haiyang AU - Song, Zhifang AU - Jia, Xiaomin AU - Zhang, Zhengdong AU - Zhou, Jianwei AU - Ni, Chunhui PY - 2009/10/30/ UR - http://dx.doi.org/10.1038/jhg.2009.112 ER -