Sympathoadrenal Stress Reactivity Is a Predictor of Future Blood Pressure: An 18-Year Follow-Up Study Export

@article{citeulike:4110765, abstract = {In the present study we hypothesized that arterial catecholamine concentrations during rest and 2 laboratory stress tests were independent predictors of blood pressure at an 18-year follow-up. At entry, blood pressure, heart rate, and arterial plasma epinephrine and norepinephrine concentrations were measured in 99 healthy men (age: 19.3{+/-}0.4 years, mean{+/-}SD) at rest, during a mental arithmetic test, and during a cold pressor test. After 18.0{+/-}0.9 years of follow-up, resting blood pressure was measured. The norepinephrine and epinephrine concentrations during the mental arithmetic explained 12.7\% of the variation of future systolic blood pressure after adjusting for initial resting blood pressure, family history, body mass index, and systolic blood pressure during the stress test in a multiple regression analysis (adjusted R2=0.651; P<0.001). To conclude, the present study shows that sympathetic nervous activity during mental arithmetic predicts future blood pressure, indicating a possible causal factor in the development of essential hypertension independent of the initial blood pressure. 10.1161/HYPERTENSIONAHA.108.111625}, author = {Flaa, Arnljot and Eide, Ivar K. and Kjeldsen, Sverre E. and Rostrup, Morten}, citeulike-article-id = {4110765}, citeulike-linkout-0 = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.111625}, citeulike-linkout-1 = {http://hyper.ahajournals.org/content/52/2/336.abstract}, citeulike-linkout-2 = {http://hyper.ahajournals.org/content/52/2/336.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18574074}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18574074}, day = {1}, doi = {10.1161/HYPERTENSIONAHA.108.111625}, issn = {1524-4563}, journal = {Hypertension}, keywords = {blood, hypertension, longitudinal, pathways, predict, pressure, reactivity, stress, sympathetic}, month = {August}, number = {2}, pages = {336--341}, posted-at = {2009-11-09 11:50:35}, priority = {2}, title = {Sympathoadrenal Stress Reactivity Is a Predictor of Future Blood Pressure: An 18-Year Follow-Up Study}, url = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.111625}, volume = {52}, year = {2008} }

TY - JOUR ID - citeulike:4110765 L3 - citeulike-article-id:4110765 N2 - In the present study we hypothesized that arterial catecholamine concentrations during rest and 2 laboratory stress tests were independent predictors of blood pressure at an 18-year follow-up. At entry, blood pressure, heart rate, and arterial plasma epinephrine and norepinephrine concentrations were measured in 99 healthy men (age: 19.3{+/-}0.4 years, mean{+/-}SD) at rest, during a mental arithmetic test, and during a cold pressor test. After 18.0{+/-}0.9 years of follow-up, resting blood pressure was measured. The norepinephrine and epinephrine concentrations during the mental arithmetic explained 12.7% of the variation of future systolic blood pressure after adjusting for initial resting blood pressure, family history, body mass index, and systolic blood pressure during the stress test in a multiple regression analysis (adjusted R2=0.651; P<0.001). To conclude, the present study shows that sympathetic nervous activity during mental arithmetic predicts future blood pressure, indicating a possible causal factor in the development of essential hypertension independent of the initial blood pressure. 10.1161/HYPERTENSIONAHA.108.111625 IS - 2 JF - Hypertension SN - 1524-4563 EP - 341 TI - Sympathoadrenal Stress Reactivity Is a Predictor of Future Blood Pressure: An 18-Year Follow-Up Study VL - 52 SP - 336 KW - blood KW - hypertension KW - longitudinal KW - pathways KW - predict KW - pressure KW - reactivity KW - stress KW - sympathetic AU - Flaa, Arnljot AU - Eide, Ivar AU - Kjeldsen, Sverre AU - Rostrup, Morten PY - 2008/08/01/ UR - http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.111625 ER -