Enabling the chemistry of life. Export

@article{citeulike:3177, abstract = {Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in product-determining reactions. Many enzymes are members of families that carry out related chemical transformations and offer opportunities for directed in vitro evolution, to tailor catalytic properties to particular functions.}, address = {Biological Chemistry and Molecular Pharmacology Department, Harvard Medical School, Boston, Massachusetts 02115, USA.}, author = {Walsh, C.}, citeulike-article-id = {3177}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/35051697}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11196650}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11196650}, day = {11}, doi = {10.1038/35051697}, issn = {0028-0836}, journal = {Nature}, keywords = {biochem}, month = {January}, number = {6817}, pages = {226--231}, posted-at = {2004-12-09 07:13:59}, title = {Enabling the chemistry of life.}, url = {http://dx.doi.org/10.1038/35051697}, volume = {409}, year = {2001} }

TY - JOUR ID - citeulike:3177 L3 - citeulike-article-id:3177 N2 - Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in product-determining reactions. Many enzymes are members of families that carry out related chemical transformations and offer opportunities for directed in vitro evolution, to tailor catalytic properties to particular functions. IS - 6817 JF - Nature SN - 0028-0836 AD - Biological Chemistry and Molecular Pharmacology Department, Harvard Medical School, Boston, Massachusetts 02115, USA. EP - 231 TI - Enabling the chemistry of life. VL - 409 SP - 226 KW - biochem AU - Walsh, C PY - 2001/01/11/ UR - http://dx.doi.org/10.1038/35051697 ER -