High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity Export

@article{tuch-hardi, abstract = {Magnetic resonance (MR) diffusion tensor imaging (DTI) can resolve the white matter fiber orientation within a voxel provided that the fibers are strongly aligned. However, a given voxel may contain a distribution of fiber orientations due to, for example, intravoxel fiber crossing. The present study sought to test whether a geodesic, high b-value diffusion gradient sampling scheme could resolve multiple fiber orientations within a single voxel. In regions of fiber crossing the diffusion signal exhibited multiple local maxima/minima as a function of diffusion gradient orientation, indicating the presence of multiple intravoxel fiber orientations. The multimodality of the observed diffusion signal precluded the standard tensor reconstruction, so instead the diffusion signal was modeled as arising from a discrete mixture of Gaussian diffusion processes in slow exchange, and the underlying mixture of tensors was solved for using a gradient descent scheme. The multitensor reconstruction resolved multiple intravoxel fiber populations corresponding to known fiber anatomy. Magn Reson Med 48:577-582, 2002. {\copyright} 2002 Wiley-Liss, Inc.}, address = {Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts; Center for Morphometric Analysis, Massachusetts General Hospital, Charlestown, Massachusetts}, author = {Tuch, D. S. and Reese, T. G. and Wiegell, M. R. and Makris, N. and Belliveau, J. W. and Wedeen, V. J.}, citeulike-article-id = {1241957}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mrm.10268}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12353272}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12353272}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/98518419/ABSTRACT}, doi = {10.1002/mrm.10268}, issn = {1522-2594}, journal = {Magnetic Resonance in Medicine}, keywords = {hardi}, month = {October}, number = {4}, pages = {577--582}, posted-at = {2007-04-21 20:22:21}, priority = {5}, title = {High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity}, url = {http://dx.doi.org/10.1002/mrm.10268}, volume = {48}, year = {2002} }

TY - JOUR ID - tuch-hardi L3 - citeulike-article-id:1241957 N2 - Magnetic resonance (MR) diffusion tensor imaging (DTI) can resolve the white matter fiber orientation within a voxel provided that the fibers are strongly aligned. However, a given voxel may contain a distribution of fiber orientations due to, for example, intravoxel fiber crossing. The present study sought to test whether a geodesic, high b-value diffusion gradient sampling scheme could resolve multiple fiber orientations within a single voxel. In regions of fiber crossing the diffusion signal exhibited multiple local maxima/minima as a function of diffusion gradient orientation, indicating the presence of multiple intravoxel fiber orientations. The multimodality of the observed diffusion signal precluded the standard tensor reconstruction, so instead the diffusion signal was modeled as arising from a discrete mixture of Gaussian diffusion processes in slow exchange, and the underlying mixture of tensors was solved for using a gradient descent scheme. The multitensor reconstruction resolved multiple intravoxel fiber populations corresponding to known fiber anatomy. Magn Reson Med 48:577-582, 2002. © 2002 Wiley-Liss, Inc. IS - 4 JF - Magnetic Resonance in Medicine SN - 1522-2594 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts; Center for Morphometric Analysis, Massachusetts General Hospital, Charlestown, Massachusetts EP - 582 TI - High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity VL - 48 SP - 577 KW - hardi AU - Tuch, DS AU - Reese, TG AU - Wiegell, MR AU - Makris, N AU - Belliveau, JW AU - Wedeen, VJ PY - 2002/10// UR - http://dx.doi.org/10.1002/mrm.10268 ER -