Self Responses along Cingulate Cortex Reveal Quantitative Neural Phenotype for High-Functioning Autism

@article{citeulike:2971244, abstract = {Summary Attributing behavioral outcomes correctly to oneself or to other agents is essential for all productive social exchange. We approach this issue in high-functioning males with autism spectrum disorder (ASD) using two separate fMRI paradigms. First, using a visual imagery task, we extract a basis set for responses along the cingulate cortex of control subjects that reveals an agent-specific eigenvector (self eigenmode) associated with imagining oneself executing a specific motor act. Second, we show that the same self eigenmode arises during one's own decision (the self phase) in an interpersonal exchange game (iterated trust game). Third, using this exchange game, we show that ASD males exhibit a severely diminished cingulate self response when playing the game with a human partner. This diminishment covaries parametrically with their behaviorally assessed symptom severity, suggesting its value as an objective endophenotype. These findings may provide a quantitative assessment tool for high-functioning ASD.}, author = {Chiu, Pearl H. and Kayali, Amin M. and Kishida, Kenneth T. and Tomlin, Damon and Klinger, Laura G. and Klinger, Mark R. and Montague, Read P. .}, citeulike-article-id = {2971244}, doi = {10.1016/j.neuron.2007.12.020}, journal = {Neuron}, keywords = {fmri, human}, month = {February}, number = {3}, pages = {463--473}, posted-at = {2008-11-03 17:33:07}, priority = {2}, title = {Self Responses along Cingulate Cortex Reveal Quantitative Neural Phenotype for High-Functioning Autism}, url = {http://dx.doi.org/10.1016/j.neuron.2007.12.020}, volume = {57}, year = {2008} }

TY - JOUR ID - citeulike:2971244 L3 - citeulike-article-id:2971244 N2 - Summary Attributing behavioral outcomes correctly to oneself or to other agents is essential for all productive social exchange. We approach this issue in high-functioning males with autism spectrum disorder (ASD) using two separate fMRI paradigms. First, using a visual imagery task, we extract a basis set for responses along the cingulate cortex of control subjects that reveals an agent-specific eigenvector (self eigenmode) associated with imagining oneself executing a specific motor act. Second, we show that the same self eigenmode arises during one's own decision (the self phase) in an interpersonal exchange game (iterated trust game). Third, using this exchange game, we show that ASD males exhibit a severely diminished cingulate self response when playing the game with a human partner. This diminishment covaries parametrically with their behaviorally assessed symptom severity, suggesting its value as an objective endophenotype. These findings may provide a quantitative assessment tool for high-functioning ASD. IS - 3 JF - Neuron EP - 473 TI - Self Responses along Cingulate Cortex Reveal Quantitative Neural Phenotype for High-Functioning Autism VL - 57 SP - 463 KW - fmri KW - human AU - Chiu, Pearl AU - Kayali, Amin AU - Kishida, Kenneth AU - Tomlin, Damon AU - Klinger, Laura AU - Klinger, Mark AU - Montague, Read PY - 2008/02/07/ UR - http://dx.doi.org/10.1016/j.neuron.2007.12.020 ER -