Self-Control in Decision-Making Involves Modulation of the vmPFC Valuation System Export

@article{citeulike:4452356, abstract = {Every day, individuals make dozens of choices between an alternative with higher overall value and a more tempting but ultimately inferior option. Optimal decision-making requires self-control. We propose two hypotheses about the neurobiology of self-control: (i) Goal-directed decisions have their basis in a common value signal encoded in ventromedial prefrontal cortex (vmPFC), and (ii) exercising self-control involves the modulation of this value signal by dorsolateral prefrontal cortex (DLPFC). We used functional magnetic resonance imaging to monitor brain activity while dieters engaged in real decisions about food consumption. Activity in vmPFC was correlated with goal values regardless of the amount of self-control. It incorporated both taste and health in self-controllers but only taste in non-self-controllers. Activity in DLPFC increased when subjects exercised self-control and correlated with activity in vmPFC. 10.1126/science.1168450}, author = {Hare, Todd A. and Camerer, Colin F. and Rangel, Antonio}, citeulike-article-id = {4452356}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1168450}, citeulike-linkout-1 = {http://www.sciencemag.org/content/324/5927/646.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/324/5927/646.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/324/5927/646}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19407204}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19407204}, day = {1}, doi = {10.1126/science.1168450}, issn = {1095-9203}, journal = {Science}, keywords = {choice, connectivity, dlpfc, fmri, human, pfc, self-control, vmpfc}, month = {May}, number = {5927}, pages = {646--648}, posted-at = {2009-09-30 20:30:27}, priority = {0}, title = {Self-Control in Decision-Making Involves Modulation of the vmPFC Valuation System}, url = {http://dx.doi.org/10.1126/science.1168450}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4452356 L3 - citeulike-article-id:4452356 N2 - Every day, individuals make dozens of choices between an alternative with higher overall value and a more tempting but ultimately inferior option. Optimal decision-making requires self-control. We propose two hypotheses about the neurobiology of self-control: (i) Goal-directed decisions have their basis in a common value signal encoded in ventromedial prefrontal cortex (vmPFC), and (ii) exercising self-control involves the modulation of this value signal by dorsolateral prefrontal cortex (DLPFC). We used functional magnetic resonance imaging to monitor brain activity while dieters engaged in real decisions about food consumption. Activity in vmPFC was correlated with goal values regardless of the amount of self-control. It incorporated both taste and health in self-controllers but only taste in non-self-controllers. Activity in DLPFC increased when subjects exercised self-control and correlated with activity in vmPFC. 10.1126/science.1168450 IS - 5927 JF - Science SN - 1095-9203 EP - 648 TI - Self-Control in Decision-Making Involves Modulation of the vmPFC Valuation System VL - 324 SP - 646 KW - choice KW - connectivity KW - dlpfc KW - fmri KW - human KW - pfc KW - self-control KW - vmpfc AU - Hare, Todd AU - Camerer, Colin AU - Rangel, Antonio PY - 2009/05/01/ UR - http://dx.doi.org/10.1126/science.1168450 ER -