Antisense transcription controls cell fate in Saccharomyces cerevisiae. Export

@article{citeulike:1018472, abstract = {Entry into meiosis is a key developmental decision. We show here that meiotic entry in Saccharomyces cerevisiae is controlled by antisense-mediated regulation of IME4, a gene required for initiating meiosis. In MAT a/alpha diploids the antisense IME4 transcript is repressed by binding of the a1/alpha2 heterodimer at a conserved site located downstream of the IME4 coding sequence. MAT a/alpha diploids that produce IME4 antisense transcript have diminished sense transcription and fail to initiate meiosis. Haploids that produce the sense transcript have diminished antisense transcription and manifest several diploid phenotypes. Our data are consistent with transcription interference as a regulatory mechanism at the IME4 locus that determines cell fate.}, author = {Hongay, Cintia F. and Grisafi, Paula L. and Galitski, Timothy and Fink, Gerald R.}, citeulike-article-id = {1018472}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2006.09.038}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17110333}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17110333}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WSN-4MC1FM1-K/2/f37e36313d5b0a16afeec5da289c32e9}, day = {17}, doi = {10.1016/j.cell.2006.09.038}, issn = {0092-8674}, journal = {Cell}, keywords = {antisense, antisense\_transcription, saccharomyces, sexual\_development}, month = {November}, number = {4}, pages = {735--745}, posted-at = {2006-12-28 20:24:41}, priority = {3}, title = {Antisense transcription controls cell fate in Saccharomyces cerevisiae.}, url = {http://dx.doi.org/10.1016/j.cell.2006.09.038}, volume = {127}, year = {2006} }

TY - JOUR ID - citeulike:1018472 L3 - citeulike-article-id:1018472 N2 - Entry into meiosis is a key developmental decision. We show here that meiotic entry in Saccharomyces cerevisiae is controlled by antisense-mediated regulation of IME4, a gene required for initiating meiosis. In MAT a/alpha diploids the antisense IME4 transcript is repressed by binding of the a1/alpha2 heterodimer at a conserved site located downstream of the IME4 coding sequence. MAT a/alpha diploids that produce IME4 antisense transcript have diminished sense transcription and fail to initiate meiosis. Haploids that produce the sense transcript have diminished antisense transcription and manifest several diploid phenotypes. Our data are consistent with transcription interference as a regulatory mechanism at the IME4 locus that determines cell fate. IS - 4 JF - Cell SN - 0092-8674 EP - 745 TI - Antisense transcription controls cell fate in Saccharomyces cerevisiae. VL - 127 SP - 735 KW - antisense KW - antisense_transcription KW - saccharomyces KW - sexual_development AU - Hongay, Cintia AU - Grisafi, Paula AU - Galitski, Timothy AU - Fink, Gerald PY - 2006/11/17/ UR - http://dx.doi.org/10.1016/j.cell.2006.09.038 ER -