Evolutionary and Biomedical Insights from the Rhesus Macaque Genome Export

@article{citeulike:1223530, abstract = {The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species. 10.1126/science.1139247}, author = {Rhesus Macaque Genome Sequencing and Analysis Consortium and Gibbs, Richard A. and Rogers, Jeffrey and Katze, Michael G. and Bumgarner, Roger and Weinstock, George M. and Mardis, Elaine R. and Remington, Karin A. and Strausberg, Robert L. and Venter, J. Craig and Wilson, Richard K. and Batzer, Mark A. and Bustamante, Carlos D. and Eichler, Evan E. and Hahn, Matthew W. and Hardison, Ross C. and Makova, Kateryna D. and Miller, Webb and Milosavljevic, Aleksandar and Palermo, Robert E. and Siepel, Adam and Sikela, James M. and Attaway, Tony and Bell, Stephanie and Bernard, Kelly E. and Buhay, Christian J. and Chandrabose, Mimi N. and Dao, Marvin and Davis, Clay and Delehaunty, Kimberly D. and Ding, Yan and Dinh, Huyen H. and Dugan-Rocha, Shannon and Fulton, Lucinda A. and Gabisi, Ramatu A. and Garner, Toni T. and Godfrey, Jennifer and Hawes, Alicia C. and Hernandez, Judith and Hines, Sandra and Holder, Michael and Hume, Jennifer and Jhangiani, Shalini N. and Joshi, Vandita and Khan, Ziad M. and Kirkness, Ewen F. and Cree, Andrew and Fowler, R. Gerald and Lee, Sandra and Lewis, Lora R. and Li, Zhangwan and Liu, Yih-shin and Moore, Stephanie M. and Muzny, Donna and Nazareth, Lynne V. and Ngo, Dinh N. and Okwuonu, Geoffrey O. and Pai, Grace and Parker, David and Paul, Heidie A. and Pfannkoch, Cynthia and Pohl, Craig S. and Rogers, Yu-Hui and Ruiz, San J. and Sabo, Aniko and Santibanez, Jireh and Schneider, Brian W. and Smith, Scott M. and Sodergren, Erica and Svatek, Amanda F. and Utterback, Teresa R. and Vattathil, Selina and Warren, Wesley and White, Courtney S. and Chinwalla, Asif T. and Feng, Yucheng and Halpern, Aaron L. and Hillier, LaDeana W. and Huang, Xiaoqiu and Minx, Pat and Nelson, Joanne O. and Pepin, Kymberlie H. and Qin, Xiang and Sutton, Granger G. and Venter, Eli and Walenz, Brian P. and Wallis, John W. and Worley, Kim C. and Yang, Shiaw-Pyng and Jones, Steven M. and Marra, Marco A. and Rocchi, Mariano and Schein, Jacqueline E. and Baertsch, Robert and Clarke, Laura and Csuros, Miklos and Glasscock, Jarret and Harris, R. Alan and Havlak, Paul and Jackson, Andrew R. and Jiang, Huaiyang and Liu, Yue and Messina, David N. and Shen, Yufeng and Song, Henry X. and Wylie, Todd and Zhang, Lan and Birney, Ewan and Han, Kyudong and Konkel, Miriam K. and Lee, Jungnam and Smit, Arian F. A. and Ullmer, Brygg and Wang, Hui and Xing, Jinchuan and Burhans, Richard and Cheng, Ze and Karro, John E. and Ma, Jian and Raney, Brian and She, Xinwei and Cox, Michael J. and Demuth, Jeffery P. and Dumas, Laura J. and Han, Sang-Gook and Hopkins, Janet and Karimpour-Fard, Anis and Kim, Young H. and Pollack, Jonathan R. and Vinar, Tomas and Addo-Quaye, Charles and Degenhardt, Jeremiah and Denby, Alexandra and Hubisz, Melissa J. and Indap, Amit and Kosiol, Carolin and Lahn, Bruce T. and Lawson, Heather A. and Marklein, Alison and Nielsen, Rasmus and Vallender, Eric J. and Clark, Andrew G. and Ferguson, Betsy and Hernandez, Ryan D. and Hirani, Kashif and Kehrer-Sawatzki, Hildegard and Kolb, Jessica and Patil, Shobha and Pu, Ling-Ling and Ren, Yanru and Smith, David G. and Wheeler, David A. and Schenck, Ian and Ball, Edward V. and Chen, Rui and Cooper, David N. and Giardine, Belinda and Hsu, Fan and Kent, W. James and Lesk, Arthur and Nelson, David L. and O'Brien, William E. and Prufer, Kay and Stenson, Peter D. and Wallace, James C. and Ke, Hui and Liu, Xiao-Ming and Wang, Peng and Xiang, Andy P. and Yang, Fan and Barber, Galt P. and Haussler, David and Karolchik, Donna and Kern, Andy D. and Kuhn, Robert M. and Smith, Kayla E. and Zwieg, Ann S.}, citeulike-article-id = {1223530}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1139247}, citeulike-linkout-1 = {http://www.sciencemag.org/content/316/5822/222.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/316/5822/222.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/316/5822/222}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17431167}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17431167}, day = {13}, doi = {10.1126/science.1139247}, journal = {Science}, keywords = {genome\_paper, macaque, primate}, month = {April}, number = {5822}, pages = {222--234}, posted-at = {2007-12-16 01:01:33}, priority = {2}, title = {Evolutionary and Biomedical Insights from the Rhesus Macaque Genome}, url = {http://dx.doi.org/10.1126/science.1139247}, volume = {316}, year = {2007} }

TY - JOUR ID - citeulike:1223530 L3 - citeulike-article-id:1223530 N2 - The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species. 10.1126/science.1139247 IS - 5822 JF - Science EP - 234 TI - Evolutionary and Biomedical Insights from the Rhesus Macaque Genome VL - 316 SP - 222 KW - genome_paper KW - macaque KW - primate AU - Rhesus Macaque Genome Sequencing and Analysis Consortium AU - Gibbs, Richard AU - Rogers, Jeffrey AU - Katze, Michael AU - Bumgarner, Roger AU - Weinstock, George AU - Mardis, Elaine AU - Remington, Karin AU - Strausberg, Robert AU - Venter, Craig AU - Wilson, Richard AU - Batzer, Mark AU - Bustamante, Carlos AU - Eichler, Evan AU - Hahn, Matthew AU - Hardison, Ross AU - Makova, Kateryna AU - Miller, Webb AU - Milosavljevic, Aleksandar AU - Palermo, Robert AU - Siepel, Adam AU - Sikela, James AU - Attaway, Tony AU - Bell, Stephanie AU - Bernard, Kelly AU - Buhay, Christian AU - Chandrabose, Mimi AU - Dao, Marvin AU - Davis, Clay AU - Delehaunty, Kimberly AU - Ding, Yan AU - Dinh, Huyen AU - Dugan-Rocha, Shannon AU - Fulton, Lucinda AU - Gabisi, Ramatu AU - Garner, Toni AU - Godfrey, Jennifer AU - Hawes, Alicia AU - Hernandez, Judith AU - Hines, Sandra AU - Holder, Michael AU - Hume, Jennifer AU - Jhangiani, Shalini AU - Joshi, Vandita AU - Khan, Ziad AU - Kirkness, Ewen AU - Cree, Andrew AU - Fowler, Gerald AU - Lee, Sandra AU - Lewis, Lora AU - Li, Zhangwan AU - Liu, Yih-shin AU - Moore, Stephanie AU - Muzny, Donna AU - Nazareth, Lynne AU - Ngo, Dinh AU - Okwuonu, Geoffrey AU - Pai, Grace AU - Parker, David AU - Paul, Heidie AU - Pfannkoch, Cynthia AU - Pohl, Craig AU - Rogers, Yu-Hui AU - Ruiz, San AU - Sabo, Aniko AU - Santibanez, Jireh AU - Schneider, Brian AU - Smith, Scott AU - Sodergren, Erica AU - Svatek, Amanda AU - Utterback, Teresa AU - Vattathil, Selina AU - Warren, Wesley AU - White, Courtney AU - Chinwalla, Asif AU - Feng, Yucheng AU - Halpern, Aaron AU - Hillier, LaDeana AU - Huang, Xiaoqiu AU - Minx, Pat AU - Nelson, Joanne AU - Pepin, Kymberlie AU - Qin, Xiang AU - Sutton, Granger AU - Venter, Eli AU - Walenz, Brian AU - Wallis, John AU - Worley, Kim AU - Yang, Shiaw-Pyng AU - Jones, Steven AU - Marra, Marco AU - Rocchi, Mariano AU - Schein, Jacqueline AU - Baertsch, Robert AU - Clarke, Laura AU - Csuros, Miklos AU - Glasscock, Jarret AU - Harris, Alan AU - Havlak, Paul AU - Jackson, Andrew AU - Jiang, Huaiyang AU - Liu, Yue AU - Messina, David AU - Shen, Yufeng AU - Song, Henry AU - Wylie, Todd AU - Zhang, Lan AU - Birney, Ewan AU - Han, Kyudong AU - Konkel, Miriam AU - Lee, Jungnam AU - Smit, Arian AU - Ullmer, Brygg AU - Wang, Hui AU - Xing, Jinchuan AU - Burhans, Richard AU - Cheng, Ze AU - Karro, John AU - Ma, Jian AU - Raney, Brian AU - She, Xinwei AU - Cox, Michael AU - Demuth, Jeffery AU - Dumas, Laura AU - Han, Sang-Gook AU - Hopkins, Janet AU - Karimpour-Fard, Anis AU - Kim, Young AU - Pollack, Jonathan AU - Vinar, Tomas AU - Addo-Quaye, Charles AU - Degenhardt, Jeremiah AU - Denby, Alexandra AU - Hubisz, Melissa AU - Indap, Amit AU - Kosiol, Carolin AU - Lahn, Bruce AU - Lawson, Heather AU - Marklein, Alison AU - Nielsen, Rasmus AU - Vallender, Eric AU - Clark, Andrew AU - Ferguson, Betsy AU - Hernandez, Ryan AU - Hirani, Kashif AU - Kehrer-Sawatzki, Hildegard AU - Kolb, Jessica AU - Patil, Shobha AU - Pu, Ling-Ling AU - Ren, Yanru AU - Smith, David AU - Wheeler, David AU - Schenck, Ian AU - Ball, Edward AU - Chen, Rui AU - Cooper, David AU - Giardine, Belinda AU - Hsu, Fan AU - Kent, James AU - Lesk, Arthur AU - Nelson, David AU - O'Brien, William AU - Prufer, Kay AU - Stenson, Peter AU - Wallace, James AU - Ke, Hui AU - Liu, Xiao-Ming AU - Wang, Peng AU - Xiang, Andy AU - Yang, Fan AU - Barber, Galt AU - Haussler, David AU - Karolchik, Donna AU - Kern, Andy AU - Kuhn, Robert AU - Smith, Kayla AU - Zwieg, Ann PY - 2007/04/13/ UR - http://dx.doi.org/10.1126/science.1139247 ER -