The actin cytoskeleton in ageing and apoptosis Export

@article{citeulike:984704, abstract = {Regulated cell death, or apoptosis, has evolved to fulfil a myriad of functions amongst multicellular organisms. It is now apparent that programmed cell death occurs in unicellular organisms such as yeast. In yeast, as in higher eukaryotes, the actin cytoskeleton is an essential component of a number of cellular activities, and many of the regulatory proteins involved are highly conserved. Recent evidence from diverse eukaryotic systems suggests that the actin cytoskeleton has a role in regulating apoptosis via interactions with the mitochondria. This interaction also appears to have a significant impact on the management of oxidative stress and so cellular ageing. In this mini-review we summarise some of the work, which suggests that actin is a key regulator of apoptosis and ageing in eukaryotic cells.}, author = {Gourlay, Campbell W. and Ayscough, Kathryn R.}, booktitle = {Thematic Section: Apoptosis, aging and redox homeostasis in yeasts}, citeulike-article-id = {984704}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.femsyr.2005.08.001}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6W8C-4H09XJJ-1/2/5991f59613fcea8de607c7b64db7b147}, doi = {10.1016/j.femsyr.2005.08.001}, journal = {FEMS Yeast Research}, keywords = {ageing, apoptosis, fungi, yeast}, month = {December}, number = {12}, pages = {1193--1198}, posted-at = {2006-12-08 19:43:50}, priority = {2}, title = {The actin cytoskeleton in ageing and apoptosis}, url = {http://dx.doi.org/10.1016/j.femsyr.2005.08.001}, volume = {5}, year = {2005} }

TY - JOUR ID - citeulike:984704 L3 - citeulike-article-id:984704 N2 - Regulated cell death, or apoptosis, has evolved to fulfil a myriad of functions amongst multicellular organisms. It is now apparent that programmed cell death occurs in unicellular organisms such as yeast. In yeast, as in higher eukaryotes, the actin cytoskeleton is an essential component of a number of cellular activities, and many of the regulatory proteins involved are highly conserved. Recent evidence from diverse eukaryotic systems suggests that the actin cytoskeleton has a role in regulating apoptosis via interactions with the mitochondria. This interaction also appears to have a significant impact on the management of oxidative stress and so cellular ageing. In this mini-review we summarise some of the work, which suggests that actin is a key regulator of apoptosis and ageing in eukaryotic cells. IS - 12 JF - FEMS Yeast Research EP - 1198 TI - The actin cytoskeleton in ageing and apoptosis VL - 5 T2 - Thematic Section: Apoptosis, aging and redox homeostasis in yeasts SP - 1193 KW - ageing KW - apoptosis KW - fungi KW - yeast AU - Gourlay, Campbell AU - Ayscough, Kathryn PY - 2005/12// UR - http://dx.doi.org/10.1016/j.femsyr.2005.08.001 ER -