Dendrite-to-Soma Input/Output Function of Continuous Time-Varying Signals in Hippocampal CA1 Pyramidal Neurons Export

@article{citeulike:1942054, abstract = {We examined how hippocamal CA1 neurons process complex time-varying inputs that dendrites are likely to receive in vivo. We propose a functional model of the dendrite-to-soma input/output relationship that combines temporal integration and static-gain control mechanisms. Using simultaneous dual whole cell recordings, we injected 50 s of subthreshold and suprathreshold zero-mean white-noise current into the primary dendritic trunk along the proximal 2/3 of stratum radiatum and measured the membrane potential at the soma. Applying a nonlinear system-identification analysis, we found that a cascade of a linear filter followed by an adapting static-gain term fully accounted for the nonspiking input/output relationship between the dendrite and soma. The estimated filters contained a prominent band-pass region in the 1- to 10-Hz frequency range that remained constant as a function of stimulus variance. The gain of the dendrite-to-soma input/output relationship, in contrast, varied as a function of stimulus variance. When the contribution of the voltage-dependent current Ih was eliminated, the estimated filters lost their band-pass properties and the gain regulation was substantially altered. Our findings suggest that the dendrite-to-soma input/output relationship for proximal apical inputs to CA1 pyramidal neurons is well described as a band-pass filter in the theta frequency range followed by a gain-control nonlinearity that dynamically adapts to the statistics of the input signal. 10.1152/jn.00414.2007}, author = {Cook, Erik P. and Guest, Jennifer A. and Liang, Yong and Masse, Nicolas Y. and Colbert, Costa M.}, citeulike-article-id = {1942054}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/jn.00414.2007}, citeulike-linkout-1 = {http://jn.physiology.org/cgi/content/abstract/98/5/2943}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17881486}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17881486}, day = {1}, doi = {10.1152/jn.00414.2007}, journal = {J Neurophysiol}, keywords = {carnevale, electrotonus, qual}, month = {November}, number = {5}, pages = {2943--2955}, posted-at = {2009-04-22 17:04:56}, priority = {2}, title = {Dendrite-to-Soma Input/Output Function of Continuous Time-Varying Signals in Hippocampal CA1 Pyramidal Neurons}, url = {http://dx.doi.org/10.1152/jn.00414.2007}, volume = {98}, year = {2007} }

TY - JOUR ID - citeulike:1942054 L3 - citeulike-article-id:1942054 N2 - We examined how hippocamal CA1 neurons process complex time-varying inputs that dendrites are likely to receive in vivo. We propose a functional model of the dendrite-to-soma input/output relationship that combines temporal integration and static-gain control mechanisms. Using simultaneous dual whole cell recordings, we injected 50 s of subthreshold and suprathreshold zero-mean white-noise current into the primary dendritic trunk along the proximal 2/3 of stratum radiatum and measured the membrane potential at the soma. Applying a nonlinear system-identification analysis, we found that a cascade of a linear filter followed by an adapting static-gain term fully accounted for the nonspiking input/output relationship between the dendrite and soma. The estimated filters contained a prominent band-pass region in the 1- to 10-Hz frequency range that remained constant as a function of stimulus variance. The gain of the dendrite-to-soma input/output relationship, in contrast, varied as a function of stimulus variance. When the contribution of the voltage-dependent current Ih was eliminated, the estimated filters lost their band-pass properties and the gain regulation was substantially altered. Our findings suggest that the dendrite-to-soma input/output relationship for proximal apical inputs to CA1 pyramidal neurons is well described as a band-pass filter in the theta frequency range followed by a gain-control nonlinearity that dynamically adapts to the statistics of the input signal. 10.1152/jn.00414.2007 IS - 5 JF - J Neurophysiol EP - 2955 TI - Dendrite-to-Soma Input/Output Function of Continuous Time-Varying Signals in Hippocampal CA1 Pyramidal Neurons VL - 98 SP - 2943 KW - carnevale KW - electrotonus KW - qual AU - Cook, Erik AU - Guest, Jennifer AU - Liang, Yong AU - Masse, Nicolas AU - Colbert, Costa PY - 2007/11/01/ UR - http://dx.doi.org/10.1152/jn.00414.2007 ER -