Synaptic theory of working memory. Export

@article{citeulike:2531838, abstract = {It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust. The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network.}, author = {Mongillo, Gianluigi and Barak, Omri and Tsodyks, Misha}, citeulike-article-id = {2531838}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1150769}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/319/5869/1543}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18339943}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18339943}, day = {14}, doi = {10.1126/science.1150769}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {inpjc, modeling, synapse, working\_memory}, month = {March}, number = {5869}, pages = {1543--1546}, posted-at = {2008-05-15 22:12:12}, priority = {2}, title = {Synaptic theory of working memory.}, url = {http://dx.doi.org/10.1126/science.1150769}, volume = {319}, year = {2008} }

TY - JOUR ID - citeulike:2531838 L3 - citeulike-article-id:2531838 N2 - It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust. The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network. IS - 5869 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1546 TI - Synaptic theory of working memory. VL - 319 SP - 1543 KW - inpjc KW - modeling KW - synapse KW - working_memory AU - Mongillo, Gianluigi AU - Barak, Omri AU - Tsodyks, Misha PY - 2008/03/14/ UR - http://dx.doi.org/10.1126/science.1150769 ER -