Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons Export

@article{citeulike:2927308, abstract = {Dopaminergic modulation of prefrontal cortical activity is known to affect cognitive functions like working memory. Little consensus on the role of dopamine modulation has been achieved, however, in part because quantities directly relating to the neuronal substrate of working memory are difficult to measure. Here we show that dopamine increases the gain of the frequency-current relationship of layer 5 pyramidal neurons in vitro in response to noisy input currents. The gain increase could be attributed to a reduction of the slow afterhyperpolarization by dopamine. Dopamine also increases neuronal excitability by shifting the input-output functions to lower inputs. The modulation of these response properties is mainly mediated by D1 receptors. Integrate-and-fire neurons were fitted to the experimentally recorded input-output functions and recurrently connected in a model network. The gain increase induced by dopamine application facilitated and stabilized persistent activity in this network. The results support the hypothesis that catecholamines increase the neuronal gain and suggest that dopamine improves working memory via gain modulation. 10.1152/jn.01098.2007}, author = {Thurley, Kay and Senn, Walter and Luscher, Hans-Rudolf}, citeulike-article-id = {2927308}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/jn.01098.2007}, citeulike-linkout-1 = {http://jn.physiology.org/cgi/content/abstract/99/6/2985}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18400958}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18400958}, day = {1}, doi = {10.1152/jn.01098.2007}, journal = {J Neurophysiol}, keywords = {dopamine, gain\_modulation, pfc}, month = {June}, number = {6}, pages = {2985--2997}, posted-at = {2008-06-25 20:32:33}, priority = {2}, title = {Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons}, url = {http://dx.doi.org/10.1152/jn.01098.2007}, volume = {99}, year = {2008} }

TY - JOUR ID - citeulike:2927308 L3 - citeulike-article-id:2927308 N2 - Dopaminergic modulation of prefrontal cortical activity is known to affect cognitive functions like working memory. Little consensus on the role of dopamine modulation has been achieved, however, in part because quantities directly relating to the neuronal substrate of working memory are difficult to measure. Here we show that dopamine increases the gain of the frequency-current relationship of layer 5 pyramidal neurons in vitro in response to noisy input currents. The gain increase could be attributed to a reduction of the slow afterhyperpolarization by dopamine. Dopamine also increases neuronal excitability by shifting the input-output functions to lower inputs. The modulation of these response properties is mainly mediated by D1 receptors. Integrate-and-fire neurons were fitted to the experimentally recorded input-output functions and recurrently connected in a model network. The gain increase induced by dopamine application facilitated and stabilized persistent activity in this network. The results support the hypothesis that catecholamines increase the neuronal gain and suggest that dopamine improves working memory via gain modulation. 10.1152/jn.01098.2007 IS - 6 JF - J Neurophysiol EP - 2997 TI - Dopamine Increases the Gain of the Input-Output Response of Rat Prefrontal Pyramidal Neurons VL - 99 SP - 2985 KW - dopamine KW - gain_modulation KW - pfc AU - Thurley, Kay AU - Senn, Walter AU - Luscher, Hans-Rudolf PY - 2008/06/01/ UR - http://dx.doi.org/10.1152/jn.01098.2007 ER -