Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging. Export

@article{citeulike:4017366, abstract = {Glomeruli in the olfactory bulb are anatomically discrete modules receiving input from idiotypic olfactory sensory neurons. To examine the functional organization of sensory inputs to individual glomeruli, we loaded olfactory sensory neurons with a Ca(2+) indicator and measured odorant-evoked presynaptic Ca(2+) signals within single glomeruli by using two-photon microscopy in anaesthetized mice. Odorants evoked patterns of discrete Ca(2+) signals throughout the neuropil of a glomerulus. Across glomeruli, Ca(2+) signals occurred with equal probability in all glomerular regions. Within single glomeruli, the pattern of intraglomerular Ca(2+) signals was indistinguishable for stimuli of different duration, identity, and concentration. Moreover, the response time course of the signals was similar throughout the glomerulus. Hence, sensory inputs to individual glomeruli are spatially heterogeneous but seem to be functionally indiscriminate. These results support the view of olfactory glomeruli as functional units in representing sensory information.}, author = {Wachowiak, Matt and Denk, Winfried and Friedrich, Rainer W.}, citeulike-article-id = {4017366}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0400438101}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15184670}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15184670}, day = {15}, doi = {10.1073/pnas.0400438101}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {2pe, ca\_phys, olfaction, qual}, month = {June}, number = {24}, pages = {9097--9102}, posted-at = {2009-02-06 19:35:31}, priority = {2}, title = {Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging.}, url = {http://dx.doi.org/10.1073/pnas.0400438101}, volume = {101}, year = {2004} }

TY - JOUR ID - citeulike:4017366 L3 - citeulike-article-id:4017366 N2 - Glomeruli in the olfactory bulb are anatomically discrete modules receiving input from idiotypic olfactory sensory neurons. To examine the functional organization of sensory inputs to individual glomeruli, we loaded olfactory sensory neurons with a Ca(2+) indicator and measured odorant-evoked presynaptic Ca(2+) signals within single glomeruli by using two-photon microscopy in anaesthetized mice. Odorants evoked patterns of discrete Ca(2+) signals throughout the neuropil of a glomerulus. Across glomeruli, Ca(2+) signals occurred with equal probability in all glomerular regions. Within single glomeruli, the pattern of intraglomerular Ca(2+) signals was indistinguishable for stimuli of different duration, identity, and concentration. Moreover, the response time course of the signals was similar throughout the glomerulus. Hence, sensory inputs to individual glomeruli are spatially heterogeneous but seem to be functionally indiscriminate. These results support the view of olfactory glomeruli as functional units in representing sensory information. IS - 24 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 9102 TI - Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging. VL - 101 SP - 9097 KW - 2pe KW - ca_phys KW - olfaction KW - qual AU - Wachowiak, Matt AU - Denk, Winfried AU - Friedrich, Rainer PY - 2004/06/15/ UR - http://dx.doi.org/10.1073/pnas.0400438101 ER -