Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Export

@article{citeulike:5294776, abstract = {A high density of Na+ channels in the axon hillock, or initial segment, is believed to determine the threshold for action potential initiation in neurons. Here we report evidence for an alternative mechanism that lowers the threshold in the axon. We investigated properties and distributions of ion channels in outside-out patches from axons and somata of layer 5 pyramidal neurons in rat neocortical slices. Na+ channels in axonal patches (<30 microm from the soma) were activated by 7 mV less depolarization than were somatic Na+ channels. A-type K+ channels, which were prominent in somatic and dendritic patches, were rarely seen in axonal patches. We incorporated these findings into numerical simulations which indicate that biophysical properties of axonal channels, rather than a high density of channels in the initial segment, are most likely to determine the lowest threshold for action potential initiation.}, author = {Colbert, C. M. and Pan, E.}, citeulike-article-id = {5294776}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn857}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11992119}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11992119}, doi = {10.1038/nn857}, issn = {1097-6256}, journal = {Nature neuroscience}, keywords = {axon, spike\_initiation}, month = {June}, number = {6}, pages = {533--538}, posted-at = {2009-07-28 20:33:22}, priority = {2}, title = {Ion channel properties underlying axonal action potential initiation in pyramidal neurons.}, url = {http://dx.doi.org/10.1038/nn857}, volume = {5}, year = {2002} }

TY - JOUR ID - citeulike:5294776 L3 - citeulike-article-id:5294776 N2 - A high density of Na+ channels in the axon hillock, or initial segment, is believed to determine the threshold for action potential initiation in neurons. Here we report evidence for an alternative mechanism that lowers the threshold in the axon. We investigated properties and distributions of ion channels in outside-out patches from axons and somata of layer 5 pyramidal neurons in rat neocortical slices. Na+ channels in axonal patches (<30 microm from the soma) were activated by 7 mV less depolarization than were somatic Na+ channels. A-type K+ channels, which were prominent in somatic and dendritic patches, were rarely seen in axonal patches. We incorporated these findings into numerical simulations which indicate that biophysical properties of axonal channels, rather than a high density of channels in the initial segment, are most likely to determine the lowest threshold for action potential initiation. IS - 6 JF - Nature neuroscience SN - 1097-6256 EP - 538 TI - Ion channel properties underlying axonal action potential initiation in pyramidal neurons. VL - 5 SP - 533 KW - axon KW - spike_initiation AU - Colbert, CM AU - Pan, E PY - 2002/06// UR - http://dx.doi.org/10.1038/nn857 ER -