Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. Export

@article{citeulike:615955, abstract = {Although radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons, little is known about their integrative properties. We have used multisite two-photon glutamate uncaging to deliver different spatiotemporal input patterns to single branches while simultaneously recording the uncaging-evoked excitatory postsynaptic potentials and local Ca2+ signals. Asynchronous input patterns sum linearly in spite of the spatial clustering and produce Ca2+ signals that are mediated by NMDA receptors (NMDARs). Appropriately timed and sized input patterns ( approximately 20 inputs within approximately 6 ms) produce a supralinear summation due to the initiation of a dendritic spike. The Ca2+ signals associated with synchronous input were larger and mediated by influx through both NMDARs and voltage-gated Ca2+ channels (VGCCs). The oblique spike is a fast Na+ spike whose duration is shaped by the coincident activation of NMDAR, VGCCs, and transient K+ currents. Our results suggest that individual branches can function as single integrative compartments.}, address = {Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112.}, author = {Losonczy, Attila and Magee, Jeffrey C.}, citeulike-article-id = {615955}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2006.03.016}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627306002133}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16630839}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16630839}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6WSS-4JS15WY-H/2/c256743d5eff7c5505e648731c639e9e}, day = {20}, doi = {10.1016/j.neuron.2006.03.016}, issn = {0896-6273}, journal = {Neuron}, keywords = {2pe, ca1, hippocampus, photo-uncaging, pyramidal, qual}, month = {April}, number = {2}, pages = {291--307}, posted-at = {2008-02-22 19:48:01}, priority = {2}, title = {Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons.}, url = {http://dx.doi.org/10.1016/j.neuron.2006.03.016}, volume = {50}, year = {2006} }

TY - JOUR ID - citeulike:615955 L3 - citeulike-article-id:615955 N2 - Although radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons, little is known about their integrative properties. We have used multisite two-photon glutamate uncaging to deliver different spatiotemporal input patterns to single branches while simultaneously recording the uncaging-evoked excitatory postsynaptic potentials and local Ca2+ signals. Asynchronous input patterns sum linearly in spite of the spatial clustering and produce Ca2+ signals that are mediated by NMDA receptors (NMDARs). Appropriately timed and sized input patterns ( approximately 20 inputs within approximately 6 ms) produce a supralinear summation due to the initiation of a dendritic spike. The Ca2+ signals associated with synchronous input were larger and mediated by influx through both NMDARs and voltage-gated Ca2+ channels (VGCCs). The oblique spike is a fast Na+ spike whose duration is shaped by the coincident activation of NMDAR, VGCCs, and transient K+ currents. Our results suggest that individual branches can function as single integrative compartments. IS - 2 JF - Neuron SN - 0896-6273 AD - Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112. EP - 307 TI - Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. VL - 50 SP - 291 KW - 2pe KW - ca1 KW - hippocampus KW - photo-uncaging KW - pyramidal KW - qual AU - Losonczy, Attila AU - Magee, Jeffrey PY - 2006/04/20/ UR - http://dx.doi.org/10.1016/j.neuron.2006.03.016 ER -