Computational subunits in thin dendrites of pyramidal cells Export

@article{citeulike:943841, abstract = {The thin basal and oblique dendrites of cortical pyramidal neurons receive most of the synaptic inputs from other cells, but their integrative properties remain uncertain. Previous studies have most often reported global linear or sublinear summation. An alternative view, supported by biophysical modeling studies, holds that thin dendrites provide a layer of independent computational 'subunits' that sigmoidally modulate their inputs prior to global summation. To distinguish these possibilities, we combined confocal imaging and dual-site focal synaptic stimulation of identified thin dendrites in rat neocortical pyramidal neurons. We found that nearby inputs on the same branch summed sigmoidally, whereas widely separated inputs or inputs to different branches summed linearly. This strong spatial compartmentalization effect is incompatible with a global summation rule and provides the first experimental support for a two-layer 'neural network' model of pyramidal neuron thin-branch integration. Our findings could have important implications for the computing and memory-related functions of cortical tissue.}, address = {Department of Physiology, Technion Medical School, Bat-Galim, Haifa 31096, Israel.}, author = {Polsky, Alon and Mel, Bartlett W. and Schiller, Jackie}, citeulike-article-id = {943841}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn1253}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn1253}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15156147}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15156147}, doi = {10.1038/nn1253}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {cortex, dendrites, paired-pulse, qual}, month = {June}, number = {6}, pages = {621--627}, posted-at = {2009-02-06 19:30:18}, priority = {2}, title = {Computational subunits in thin dendrites of pyramidal cells}, url = {http://dx.doi.org/10.1038/nn1253}, volume = {7}, year = {2004} }

TY - JOUR ID - citeulike:943841 L3 - citeulike-article-id:943841 N2 - The thin basal and oblique dendrites of cortical pyramidal neurons receive most of the synaptic inputs from other cells, but their integrative properties remain uncertain. Previous studies have most often reported global linear or sublinear summation. An alternative view, supported by biophysical modeling studies, holds that thin dendrites provide a layer of independent computational 'subunits' that sigmoidally modulate their inputs prior to global summation. To distinguish these possibilities, we combined confocal imaging and dual-site focal synaptic stimulation of identified thin dendrites in rat neocortical pyramidal neurons. We found that nearby inputs on the same branch summed sigmoidally, whereas widely separated inputs or inputs to different branches summed linearly. This strong spatial compartmentalization effect is incompatible with a global summation rule and provides the first experimental support for a two-layer 'neural network' model of pyramidal neuron thin-branch integration. Our findings could have important implications for the computing and memory-related functions of cortical tissue. IS - 6 JF - Nat Neurosci SN - 1097-6256 AD - Department of Physiology, Technion Medical School, Bat-Galim, Haifa 31096, Israel. EP - 627 TI - Computational subunits in thin dendrites of pyramidal cells VL - 7 SP - 621 KW - cortex KW - dendrites KW - paired-pulse KW - qual AU - Polsky, Alon AU - Mel, Bartlett AU - Schiller, Jackie PY - 2004/06// UR - http://dx.doi.org/10.1038/nn1253 ER -