Flux distribution of metabolic networks close to optimal biomass production Export

@article{citeulike:5060977, abstract = {We study a statistical model describing the steady-state distribution of the fluxes in a metabolic network. The resulting model defined on continuous variables can be solved by the cavity method. In particular, analytical tractability is possible, solving the cavity equation over an ensemble of networks with the same degree distribution as a real metabolic network. The flux distribution that optimizes production of biomass has a fat tail with a power-law exponent independent of the structural properties of the underlying network. These results are in complete agreement with the flux-balance-analysis outcome and in qualitative agreement with the experimental results.}, author = {Bianconi, Ginestra}, citeulike-article-id = {5060977}, citeulike-linkout-0 = {http://dx.doi.org/10.1103/PhysRevE.78.035101}, doi = {10.1103/PhysRevE.78.035101}, issn = {1539-3755}, journal = {Physical Review E}, keywords = {biomass, distribution, flux, metabolic, networks, optimal, optimization, production}, month = {September}, number = {3}, posted-at = {2009-07-05 06:03:33}, priority = {2}, title = {Flux distribution of metabolic networks close to optimal biomass production}, url = {http://dx.doi.org/10.1103/PhysRevE.78.035101}, volume = {78}, year = {2008} }

TY - JOUR ID - citeulike:5060977 L3 - citeulike-article-id:5060977 N2 - We study a statistical model describing the steady-state distribution of the fluxes in a metabolic network. The resulting model defined on continuous variables can be solved by the cavity method. In particular, analytical tractability is possible, solving the cavity equation over an ensemble of networks with the same degree distribution as a real metabolic network. The flux distribution that optimizes production of biomass has a fat tail with a power-law exponent independent of the structural properties of the underlying network. These results are in complete agreement with the flux-balance-analysis outcome and in qualitative agreement with the experimental results. IS - 3 JF - Physical Review E SN - 1539-3755 TI - Flux distribution of metabolic networks close to optimal biomass production VL - 78 KW - biomass KW - distribution KW - flux KW - metabolic KW - networks KW - optimal KW - optimization KW - production AU - Bianconi, Ginestra PY - 2008/09// UR - http://dx.doi.org/10.1103/PhysRevE.78.035101 ER -