Molecular Evolution Over the Mutational Landscape

@article{citeulike:1206632, abstract = {A model of molecular evolution by natural selection is described. The dynamics of the model are determined to a great extent by the nature of the mutational process of DNA. This is due to the very low nucleotide mutation rate that effectively limits natural selection to those alleles that differ from the currently fixed allele by a single nucleotide. As a consequence, it is shown that evolution should proceed in a series of bursts if natural selection is the main mechanism for the change. A typical burst of evolution is shown to involve about 1.5 to 2.5 allelic substitutions on average. One consequence of these bursts is to elevate the variance to mean ratio in the number of substitutions per unit time to a level as is commonly observed in the protein evolution data. These results appears to be very robust to many of the particulars of the model because of the role played by extreme value theory in determining the fitnesses of the alleles.}, author = {Gillespie, John H. }, citeulike-article-id = {1206632}, journal = {Evolution}, keywords = {adaptation, model, population\_genetics}, number = {5}, pages = {1116--1129}, posted-at = {2007-04-04 20:07:18}, priority = {2}, title = {Molecular Evolution Over the Mutational Landscape}, url = {http://www.jstor.org/stable/2408444}, volume = {38}, year = {1984} }

TY - JOUR ID - citeulike:1206632 L3 - citeulike-article-id:1206632 TI - Molecular Evolution Over the Mutational Landscape JF - Evolution VL - 38 IS - 5 SP - 1116 EP - 1129 N2 - A model of molecular evolution by natural selection is described. The dynamics of the model are determined to a great extent by the nature of the mutational process of DNA. This is due to the very low nucleotide mutation rate that effectively limits natural selection to those alleles that differ from the currently fixed allele by a single nucleotide. As a consequence, it is shown that evolution should proceed in a series of bursts if natural selection is the main mechanism for the change. A typical burst of evolution is shown to involve about 1.5 to 2.5 allelic substitutions on average. One consequence of these bursts is to elevate the variance to mean ratio in the number of substitutions per unit time to a level as is commonly observed in the protein evolution data. These results appears to be very robust to many of the particulars of the model because of the role played by extreme value theory in determining the fitnesses of the alleles. KW - adaptation KW - model KW - population_genetics AU - Gillespie, John PY - 1984/// UR - http://www.jstor.org/stable/2408444 ER -