Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8+ T Lymphocytes Export

@article{citeulike:2221286, abstract = {Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection. 10.1126/science.1148886}, author = {Savage, Peter A. and Vosseller, Keith and Kang, Chulho and Larimore, Kevin and Riedel, Elyn and Wojnoonski, Kathleen and Jungbluth, Achim A. and Allison, James P.}, citeulike-article-id = {2221286}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1148886}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/319/5860/215}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18187659}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18187659}, day = {11}, doi = {10.1126/science.1148886}, journal = {Science}, keywords = {disease, immunity, recognition}, month = {January}, number = {5860}, pages = {215--220}, posted-at = {2008-01-12 00:47:45}, priority = {2}, title = {Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8+ T Lymphocytes}, url = {http://dx.doi.org/10.1126/science.1148886}, volume = {319}, year = {2008} }

TY - JOUR ID - citeulike:2221286 L3 - citeulike-article-id:2221286 N2 - Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection. 10.1126/science.1148886 IS - 5860 JF - Science EP - 220 TI - Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8+ T Lymphocytes VL - 319 SP - 215 KW - disease KW - immunity KW - recognition AU - Savage, Peter AU - Vosseller, Keith AU - Kang, Chulho AU - Larimore, Kevin AU - Riedel, Elyn AU - Wojnoonski, Kathleen AU - Jungbluth, Achim AU - Allison, James PY - 2008/01/11/ UR - http://dx.doi.org/10.1126/science.1148886 ER -