Retinoblastoma and Its Binding Partner MSI1 Control Imprinting in Arabidopsis

@article{citeulike:3113537, abstract = {Parental genomic imprinting causes preferential expression of one of the two parental alleles. In mammals, differential sex-dependent deposition of silencing DNA methylation marks during gametogenesis initiates a new cycle of imprinting. Parental genomic imprinting has been detected in plants and relies on DNA methylation by the methyltransferase MET1. However, in contrast to mammals, plant imprints are created by differential removal of silencing marks during gametogenesis. In Arabidopsis, DNA demethylation is mediated by the DNA glycosylase DEMETER (DME) causing activation of imprinted genes at the end of female gametogenesis. On the basis of genetic interactions, we show that in addition to DME, the plant homologs of the human Retinoblastoma (Rb) and its binding partner RbAp48 are required for the activation of the imprinted genes FIS2 and FWA. This Rb-dependent activation is mediated by direct transcriptional repression of MET1 during female gametogenesis. We have thus identified a new mechanism required for imprinting establishment, outlining a new role for the Retinoblastoma pathway, which may be conserved in mammals.}, author = {Jullien, Pauline E. and Mosquna, Assaf and Ingouff, Mathieu and Sakata, Tadashi and Ohad, Nir and Berger, Fr\'{e}d\'{e}ric}, citeulike-article-id = {3113537}, doi = {10.1371/journal.pbio.0060194}, journal = {PLoS Biology}, keywords = {imprinting}, month = {August}, number = {8}, pages = {e194+}, posted-at = {2008-08-26 18:42:27}, priority = {2}, title = {Retinoblastoma and Its Binding Partner MSI1 Control Imprinting in Arabidopsis}, url = {http://dx.doi.org/10.1371/journal.pbio.0060194}, volume = {6}, year = {2008} }

TY - JOUR ID - citeulike:3113537 L3 - citeulike-article-id:3113537 N2 - Parental genomic imprinting causes preferential expression of one of the two parental alleles. In mammals, differential sex-dependent deposition of silencing DNA methylation marks during gametogenesis initiates a new cycle of imprinting. Parental genomic imprinting has been detected in plants and relies on DNA methylation by the methyltransferase MET1. However, in contrast to mammals, plant imprints are created by differential removal of silencing marks during gametogenesis. In Arabidopsis, DNA demethylation is mediated by the DNA glycosylase DEMETER (DME) causing activation of imprinted genes at the end of female gametogenesis. On the basis of genetic interactions, we show that in addition to DME, the plant homologs of the human Retinoblastoma (Rb) and its binding partner RbAp48 are required for the activation of the imprinted genes FIS2 and FWA. This Rb-dependent activation is mediated by direct transcriptional repression of MET1 during female gametogenesis. We have thus identified a new mechanism required for imprinting establishment, outlining a new role for the Retinoblastoma pathway, which may be conserved in mammals. IS - 8 JF - PLoS Biology TI - Retinoblastoma and Its Binding Partner MSI1 Control Imprinting in Arabidopsis VL - 6 SP - e194 KW - imprinting AU - Jullien, Pauline AU - Mosquna, Assaf AU - Ingouff, Mathieu AU - Sakata, Tadashi AU - Ohad, Nir AU - Berger, Frédéric PY - 2008/08/01/ UR - http://dx.doi.org/10.1371/journal.pbio.0060194 ER -