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Triggered amplification by hybridization chain reaction Export

by: Robert M. Dirks, Niles A. Pierce
Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 43. (26 October 2004), pp. 15275-15278.

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cascade displacement hairpin r21 self-assembly

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10.1073/pnas.0407024101 We introduce the concept of hybridization chain reaction (HCR), in which stable DNA monomers assemble only upon exposure to a target DNA fragment. In the simplest version of this process, two stable species of DNA hairpins coexist in solution until the introduction of initiator strands triggers a cascade of hybridization events that yields nicked double helices analogous to alternating copolymers. The average molecular weight of the HCR products varies inversely with initiator concentration. Amplification of more diverse recognition events can be achieved by coupling HCR to aptamer triggers. This functionality allows DNA to act as an amplifying transducer for biosensing applications.


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