Daily Electrical Silencing in the Mammalian Circadian Clock Export

@article{citeulike:5914776, abstract = {Neurons in the brain's suprachiasmatic nuclei (SCNs), which control the timing of daily rhythms, are thought to encode time of day by changing their firing frequency, with high rates during the day and lower rates at night. Some SCN neurons express a key clock gene, period 1 (per1). We found that during the day, neurons containing per1 sustain an electrically excited state and do not fire, whereas non-per1 neurons show the previously reported daily variation in firing activity. Using a combined experimental and theoretical approach, we explain how ionic currents lead to the unusual electrophysiological behaviors of per1 cells, which unlike other mammalian brain cells can survive and function at depolarized states. 10.1126/science.1169657}, author = {Belle, Mino D. C. and Diekman, Casey O. and Forger, Daniel B. and Piggins, Hugh D.}, citeulike-article-id = {5914776}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1169657}, citeulike-linkout-1 = {http://www.sciencemag.org/content/326/5950/281.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/326/5950/281.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19815775}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19815775}, day = {9}, doi = {10.1126/science.1169657}, issn = {1095-9203}, journal = {Science}, keywords = {circadian, rhythm}, month = {October}, number = {5950}, pages = {281--284}, posted-at = {2009-10-12 11:07:20}, priority = {4}, title = {Daily Electrical Silencing in the Mammalian Circadian Clock}, url = {http://dx.doi.org/10.1126/science.1169657}, volume = {326}, year = {2009} }

TY - JOUR ID - citeulike:5914776 L3 - citeulike-article-id:5914776 N2 - Neurons in the brain's suprachiasmatic nuclei (SCNs), which control the timing of daily rhythms, are thought to encode time of day by changing their firing frequency, with high rates during the day and lower rates at night. Some SCN neurons express a key clock gene, period 1 (per1). We found that during the day, neurons containing per1 sustain an electrically excited state and do not fire, whereas non-per1 neurons show the previously reported daily variation in firing activity. Using a combined experimental and theoretical approach, we explain how ionic currents lead to the unusual electrophysiological behaviors of per1 cells, which unlike other mammalian brain cells can survive and function at depolarized states. 10.1126/science.1169657 IS - 5950 JF - Science SN - 1095-9203 EP - 284 TI - Daily Electrical Silencing in the Mammalian Circadian Clock VL - 326 SP - 281 KW - circadian KW - rhythm AU - Belle, Mino AU - Diekman, Casey AU - Forger, Daniel AU - Piggins, Hugh PY - 2009/10/09/ UR - http://dx.doi.org/10.1126/science.1169657 ER -