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Molecular recognition—viewed through the eyes of the solvent

by: A. Ben-Naim
Biophysical Chemistry, Vol. 101-102 (December 2002), pp. 309-319, doi:10.1016/s0301-4622(02)00165-5  Key: citeulike:12028212

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Abstract

The binding of a ligand L to a specific site on an adsorbent molecule P is usually studied within the lock-and-key model. In this article we argue that the presence of an aqueous solvent may change dramatically the means by which a ligand recognizes its binding site. The main factor, originating from the specific property of water, is the ability of a water molecule to form a hydrogen-bond-bridge between a functional group on L and a functional group on P. This factor will change the criterion for selecting the best binding site.


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