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Reptile: representative tiling for short read error correction

by: Xiao Yang, Karin S. Dorman, Srinivas Aluru
Bioinformatics, Vol. 26, No. 20. (15 October 2010), pp. 2526-2533, doi:10.1093/bioinformatics/btq468  Key: citeulike:7681209

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Abstract

Motivation: Error correction is critical to the success of next-generation sequencing applications, such as resequencing and de novo genome sequencing. It is especially important for high-throughput short-read sequencing, where reads are much shorter and more abundant, and errors more frequent than in traditional Sanger sequencing. Processing massive numbers of short reads with existing error correction methods is both compute and memory intensive, yet the results are far from satisfactory when applied to real datasets.


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