Effect of induced expression of an antimicrobial peptide melittin on Chlamydia trachomatis and Mycoplasma hominis infections in vivo. Export

@article{citeulike:4369898, abstract = {A plasmid construct was designed in which the gene of antimicrobial peptide melittin is controlled by the tetracycline-responsive promoter of human cytomegalovirus, aided by a constitutively expressed trans-activator protein gene. Its vaginal administration and induction of melittin gene transcription with doxycycline markedly suppressed subsequent genital tract infection of mice by Mycoplasma hominis and Chlamydia trachomatis. At least half of the melittin-protected animals proved free of either pathogen within 3-4 weeks. Recombinant plasmids expressing genes of antimicrobial peptides hold much promise as agents for prevention and control of urogenital latent infections.}, author = {Lazarev, V. N. and Shkarupeta, M. M. and Titova, G. A. and Kostrjukova, E. S. and Akopian, T. A. and Govorun, V. M.}, citeulike-article-id = {4369898}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbrc.2005.10.028}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16246304}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16246304}, doi = {10.1016/j.bbrc.2005.10.028}, issn = {0006-291X}, journal = {Biochemical and biophysical research communications}, keywords = {melittin\_sims, update2}, month = {December}, number = {2}, pages = {946--950}, posted-at = {2009-04-20 23:19:40}, priority = {2}, title = {Effect of induced expression of an antimicrobial peptide melittin on Chlamydia trachomatis and Mycoplasma hominis infections in vivo.}, url = {http://dx.doi.org/10.1016/j.bbrc.2005.10.028}, volume = {338}, year = {2005} }

TY - JOUR ID - citeulike:4369898 L3 - citeulike-article-id:4369898 N2 - A plasmid construct was designed in which the gene of antimicrobial peptide melittin is controlled by the tetracycline-responsive promoter of human cytomegalovirus, aided by a constitutively expressed trans-activator protein gene. Its vaginal administration and induction of melittin gene transcription with doxycycline markedly suppressed subsequent genital tract infection of mice by Mycoplasma hominis and Chlamydia trachomatis. At least half of the melittin-protected animals proved free of either pathogen within 3-4 weeks. Recombinant plasmids expressing genes of antimicrobial peptides hold much promise as agents for prevention and control of urogenital latent infections. IS - 2 JF - Biochemical and biophysical research communications SN - 0006-291X EP - 950 TI - Effect of induced expression of an antimicrobial peptide melittin on Chlamydia trachomatis and Mycoplasma hominis infections in vivo. VL - 338 SP - 946 KW - melittin_sims KW - update2 AU - Lazarev, VN AU - Shkarupeta, MM AU - Titova, GA AU - Kostrjukova, ES AU - Akopian, TA AU - Govorun, VM PY - 2005/12/16/ UR - http://dx.doi.org/10.1016/j.bbrc.2005.10.028 ER -