Genomics of the evolutionary process Export

@article{citeulike:693597, abstract = {Comparative analysis of genome sequences has become the primary means by which functional elements are first identified, often preceding even the identification of their function. Although this approach capitalizes on the conservation of homologous functions, it has also been successful in identifying evolutionary novelties, including new genes and pathways. As I discuss here, the analysis of multiple alignments of sequences from species on a known phylogeny has provided rich detail about the heterogeneities in the process of genome changes. Inferences of positive selection acting on protein-encoding genes have provided clues about the role of adaptive evolution in the past. These methods also identify negatively selected genes, providing some clue to genes that are most likely to be mutable to a disease-causing state.}, author = {Clark, Andrew G.}, booktitle = {Twenty years of TREE - part I}, citeulike-article-id = {693597}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tree.2006.04.004}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16769431}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16769431}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6VJ1-4JWFGN7-1/2/c7b43e576007a3009d5bceed1697d824}, doi = {10.1016/j.tree.2006.04.004}, journal = {Trends in Ecology \& Evolution}, keywords = {evolutionary, genomics, of, process, the}, month = {June}, number = {6}, pages = {316--321}, posted-at = {2007-12-07 07:46:55}, priority = {2}, title = {Genomics of the evolutionary process}, url = {http://dx.doi.org/10.1016/j.tree.2006.04.004}, volume = {21}, year = {2006} }

TY - JOUR ID - citeulike:693597 L3 - citeulike-article-id:693597 N2 - Comparative analysis of genome sequences has become the primary means by which functional elements are first identified, often preceding even the identification of their function. Although this approach capitalizes on the conservation of homologous functions, it has also been successful in identifying evolutionary novelties, including new genes and pathways. As I discuss here, the analysis of multiple alignments of sequences from species on a known phylogeny has provided rich detail about the heterogeneities in the process of genome changes. Inferences of positive selection acting on protein-encoding genes have provided clues about the role of adaptive evolution in the past. These methods also identify negatively selected genes, providing some clue to genes that are most likely to be mutable to a disease-causing state. IS - 6 JF - Trends in Ecology & Evolution EP - 321 TI - Genomics of the evolutionary process VL - 21 T2 - Twenty years of TREE - part I SP - 316 KW - evolutionary KW - genomics KW - of KW - process KW - the AU - Clark, Andrew PY - 2006/06// UR - http://dx.doi.org/10.1016/j.tree.2006.04.004 ER -