Interneuron diversity series: inhibitory interneurons and network oscillations in vitro.

@article{citeulike:2691196, abstract = {In vitro models of rhythms of cognitive relevance, such as gamma (30-80 Hz) and theta (5-12 Hz) rhythms in the hippocampus, demonstrate an absolute requirement for phasic inhibitory synaptic transmission. Such rhythms can occur transiently, of approximately 1 s duration, or persistently, lasting for many hours. In the latter case, stable patterns of interneuron output, and their postsynaptic consequences for pyramidal cell membrane potential, occur despite known constraints of synaptic habituation and potentiation. This review concentrates on recent in vitro evidence revealing a division of labour among different subclasses of interneurons with respect to the frequency of persistent rhythms, and the crucial dependence on gap-junction-mediated intercellular communication for the generation and maintenance of these rhythms.}, address = {School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK. m.a.whittington@leeds.ac.uk}, author = {Whittington, M. A. and Traub, R. D. }, citeulike-article-id = {2691196}, issn = {0166-2236}, journal = {Trends in neurosciences}, keywords = {frequency, hippocampus, inhibition, interneuron, oscillation, postsynapse, rhythm}, month = {December}, number = {12}, pages = {676--682}, posted-at = {2008-04-26 18:24:11}, priority = {2}, title = {Interneuron diversity series: inhibitory interneurons and network oscillations in vitro.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14624852}, volume = {26}, year = {2003} }

TY - JOUR ID - citeulike:2691196 L3 - citeulike-article-id:2691196 TI - Interneuron diversity series: inhibitory interneurons and network oscillations in vitro. JF - Trends in neurosciences VL - 26 IS - 12 SP - 676 EP - 682 AD - School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK. m.a.whittington@leeds.ac.uk SN - 0166-2236 N2 - In vitro models of rhythms of cognitive relevance, such as gamma (30-80 Hz) and theta (5-12 Hz) rhythms in the hippocampus, demonstrate an absolute requirement for phasic inhibitory synaptic transmission. Such rhythms can occur transiently, of approximately 1 s duration, or persistently, lasting for many hours. In the latter case, stable patterns of interneuron output, and their postsynaptic consequences for pyramidal cell membrane potential, occur despite known constraints of synaptic habituation and potentiation. This review concentrates on recent in vitro evidence revealing a division of labour among different subclasses of interneurons with respect to the frequency of persistent rhythms, and the crucial dependence on gap-junction-mediated intercellular communication for the generation and maintenance of these rhythms. KW - frequency KW - hippocampus KW - inhibition KW - interneuron KW - oscillation KW - postsynapse KW - rhythm AU - Whittington, MA AU - Traub, RD PY - 2003/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/14624852 ER -