Interpreting PET and fMRI measures of functional neural activity: the effects of synaptic inhibition on cortical activation in human imaging studies. Export

@article{citeulike:310622, abstract = {Human brain imaging methods such as postiron emission tomography and functional magnetic resonance imaging have recently achieved widespread use in the study of both normal cognitive processes and neurological disorders. While many of these studies have begun to yield important insights into human brain function, the relationship between these measurements and the underlying neuronal activity is still not well understood. One open question is how neuronal inhibition is reflected in these imaging results. In this paper, we describe how large-scale modeling can be used to address this question. Specifically, we identify three factors that may play a role in how inhibition affects imaging results: (1) local connectivity; (2) context; and (3) type of inhibitory connection. Simulation results are presented that show how the interaction among these three factors can explain seemingly contradictory experimental results. The modeling suggests that neuronal inhibition can raise brain imaging measures if there is either low local excitatory recurrence or if the region is not otherwise being driven by excitation. Conversely, with high recurrence or actively driven excitation, inhibition can lower observed values.}, address = {Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA. mtagamet@mprc.umaryland.edu}, author = {Tagamets, M. A. and Horwitz, B.}, citeulike-article-id = {310622}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11287131}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11287131}, issn = {0361-9230}, journal = {Brain Res Bull}, keywords = {3, cortical-activation, excitation, fmri, inhibition, neural-activity, pet, synapse}, month = {February}, number = {3}, pages = {267--273}, posted-at = {2008-04-14 14:50:38}, priority = {2}, title = {Interpreting PET and fMRI measures of functional neural activity: the effects of synaptic inhibition on cortical activation in human imaging studies.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11287131}, volume = {54}, year = {2001} }

TY - JOUR ID - citeulike:310622 L3 - citeulike-article-id:310622 N2 - Human brain imaging methods such as postiron emission tomography and functional magnetic resonance imaging have recently achieved widespread use in the study of both normal cognitive processes and neurological disorders. While many of these studies have begun to yield important insights into human brain function, the relationship between these measurements and the underlying neuronal activity is still not well understood. One open question is how neuronal inhibition is reflected in these imaging results. In this paper, we describe how large-scale modeling can be used to address this question. Specifically, we identify three factors that may play a role in how inhibition affects imaging results: (1) local connectivity; (2) context; and (3) type of inhibitory connection. Simulation results are presented that show how the interaction among these three factors can explain seemingly contradictory experimental results. The modeling suggests that neuronal inhibition can raise brain imaging measures if there is either low local excitatory recurrence or if the region is not otherwise being driven by excitation. Conversely, with high recurrence or actively driven excitation, inhibition can lower observed values. IS - 3 JF - Brain Res Bull SN - 0361-9230 AD - Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA. mtagamet@mprc.umaryland.edu EP - 273 TI - Interpreting PET and fMRI measures of functional neural activity: the effects of synaptic inhibition on cortical activation in human imaging studies. VL - 54 SP - 267 KW - 3 KW - cortical-activation KW - excitation KW - fmri KW - inhibition KW - neural-activity KW - pet KW - synapse AU - Tagamets, MA AU - Horwitz, B PY - 2001/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/11287131 ER -