Input normalization by global feedforward inhibition expands cortical dynamic range Export

@article{citeulike:6058586, abstract = {The cortex is sensitive to weak stimuli, but responds to stronger inputs without saturating. The mechanisms that enable this wide range of operation are not fully understood. We found that the amplitude of excitatory synaptic currents necessary to fire rodent pyramidal cells, the threshold excitatory current, increased with stimulus strength. Consequently, the relative contribution of individual afferents in firing a neuron was inversely proportional to the total number of active afferents. Feedforward inhibition, acting homogeneously across pyramidal cells, ensured that threshold excitatory currents increased with stimulus strength. In contrast, heterogeneities in the distribution of excitatory currents in the neuronal population determined the specific set of pyramidal cells recruited. Together, these mechanisms expand the range of afferent input strengths that neuronal populations can represent.}, author = {Pouille, Frederic and Marin-Burgin, Antonia and Adesnik, Hillel and Atallah, Bassam V. and Scanziani, Massimo}, booktitle = {Nat Neurosci}, citeulike-article-id = {6058586}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn.2441}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn.2441}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19881502}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19881502}, day = {01}, doi = {10.1038/nn.2441}, issn = {1097-6256}, journal = {Nature Neuroscience}, keywords = {inhibition, output}, month = {November}, number = {12}, pages = {1577--1585}, posted-at = {2009-11-04 11:37:07}, priority = {2}, publisher = {Nature Publishing Group}, title = {Input normalization by global feedforward inhibition expands cortical dynamic range}, url = {http://dx.doi.org/10.1038/nn.2441}, volume = {12}, year = {2009} }

TY - JOUR ID - citeulike:6058586 L3 - citeulike-article-id:6058586 N2 - The cortex is sensitive to weak stimuli, but responds to stronger inputs without saturating. The mechanisms that enable this wide range of operation are not fully understood. We found that the amplitude of excitatory synaptic currents necessary to fire rodent pyramidal cells, the threshold excitatory current, increased with stimulus strength. Consequently, the relative contribution of individual afferents in firing a neuron was inversely proportional to the total number of active afferents. Feedforward inhibition, acting homogeneously across pyramidal cells, ensured that threshold excitatory currents increased with stimulus strength. In contrast, heterogeneities in the distribution of excitatory currents in the neuronal population determined the specific set of pyramidal cells recruited. Together, these mechanisms expand the range of afferent input strengths that neuronal populations can represent. IS - 12 JF - Nature Neuroscience SN - 1097-6256 EP - 1585 TI - Input normalization by global feedforward inhibition expands cortical dynamic range PB - Nature Publishing Group VL - 12 T2 - Nat Neurosci SP - 1577 KW - inhibition KW - output AU - Pouille, Frederic AU - Marin-Burgin, Antonia AU - Adesnik, Hillel AU - Atallah, Bassam AU - Scanziani, Massimo PY - 2009/11/01/ UR - http://dx.doi.org/10.1038/nn.2441 ER -